Peptides

Non-Endocytic Transmembrane Delivery for Precision Medicine

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Non-endocytic transmembrane delivery strategies are emerging to bypass canonical cellular uptake routes, directly addressing the low endosomal escape efficiency that has long hindered the clinical translation of therapeutic biomacromolecules like mRNA and gene-editing tools. According to a review published in Biomedical Analysis, these advanced platforms offer a direct path to the cytosol, potentially reshaping the … Read more

FDA Panel Endorses Unproven Peptides: What You Need to Know

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An advisory committee voted narrowly on Thursday to recommend that the Food and Drug Administration reclassify four popular peptide therapies, potentially allowing compounding pharmacies to legally dispense the unapproved substances. According to federal proceedings, the panel’s eight-to-six vote with one abstention followed an 11-hour meeting regarding the substances BPC-157, KPV, and TB-500, while a fourth … Read more

Directed Enzyme Evolution: Methods and Applications

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Directed evolution, a method for engineering enzymes by mimicking the natural process of selection, is shifting from a niche lab technique to a primary engine for industrial chemistry. According to Caltech’s Frances Arnold, who received the 2018 Nobel Prize in Chemistry for this work, the future of the field lies in integrating machine learning with … Read more

Peptide-Based mRNA Vaccine: A New Hope for Neuroblastoma

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Researchers at the RCSI University of Medicine and Health Sciences have developed a novel mRNA vaccine for neuroblastoma using self-assembling peptide nanoparticles. According to study lead Olga Piskareva, the vaccine, which targets the glypican 2 (GPC2) antigen, reduced tumor volume by 70% in murine models. This approach offers a potential alternative to traditional lipid-based delivery … Read more

AI Discovers Novel Antibiotics Within Disease-Causing Prions

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Researchers at the University of Pennsylvania have identified a new class of potential antibiotics hidden within prions, the misfolded proteins typically associated with fatal neurodegenerative conditions. By using the deep-learning platform APEX 1.1 to scan 19.3 million protein fragments, the team discovered 1,179 antimicrobial candidates—dubbed “prionins”—that can kill drug-resistant bacteria, according to findings published in … Read more

Sport Integrity Australia to widen drug-testing amid illicit peptides boom

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The Biohacking Boom: When Wellness Meets Doping For decades, the line between elite athletic performance and general health was clear. Athletes used specialized regimes; the public used vitamins. But that line is blurring. We are entering the era of the “civilian athlete,” where biohacking—the practice of using science and technology to optimize the body—has moved … Read more

DNA origami vaccine platform shows promise against multiple infectious viruses

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Beyond COVID-19: The Next Generation of mRNA and DNA Vaccine Technology The rapid development and deployment of mRNA vaccines during the COVID-19 pandemic marked a turning point in global healthcare. These vaccines, initially administered in December 2020, are estimated to have prevented at least 14.4 million deaths in the first year alone. This success has … Read more

Novo Nordisk and Hims End Their Ozempic War. Here’s What It Means for You

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Weight Loss Drug Wars: Truce Between Novo Nordisk and Hims & Hers Signals Shift in Market A significant development is unfolding in the weight loss industry. Novo Nordisk, the manufacturer of Ozempic and Wegovy, and telehealth provider Hims & Hers have reached an agreement, ending a contentious legal battle and reshaping how patients access these … Read more

Space Ionizing Radiation Triggers The Formation Of Peptides And Organophosphates On Olivine Surfaces

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Space Station Experiments Reveal How Life’s Building Blocks Could Form in Space Recent research conducted aboard the Chinese Space Station (CSS) has revealed a surprising mechanism for the formation of peptides and organophosphates – essential components of life – under conditions mimicking those found in space. The findings, published in Nature Communications, suggest that space … Read more

Nutri-Score labeling system fails to reflect nutritional complexity of cocoa

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Nutri-Score Under Scrutiny: The Future of Food Labeling The Nutri-Score, a front-of-package labeling system designed to simplify nutritional choices for European consumers, is facing increasing criticism. Recent research from the University of Granada in Spain reveals the system struggles to accurately reflect the nutritional complexity of foods like soluble cocoa. This isn’t just an academic … Read more

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