Progressive supranuclear palsy (PSP) symptoms, including cognitive decline, may stem from remote brain network disruptions rather than just local tau protein accumulation. Research published in Science Advances by the National Institutes for Quantum Science and Technology (QST) indicates that tau deposits in deep brain regions can impair distant cortical areas, such as the prefrontal cortex, … Read more
Regularly sleeping nine to 10 hours or more per night is linked to higher levels of p-tau181, a blood-based protein marker for Alzheimer’s disease, according to a study from UT Health San Antonio. Researchers found that the association becomes most pronounced beyond 10 hours of sleep, suggesting long sleep may be an early indicator of … Read more
A set of 34 specific circular RNAs in the blood can predict the onset of Alzheimer’s disease symptoms, according to a study funded by the National Institutes of Health (NIH). Research indicates these markers can identify the transition to symptomatic Alzheimer’s two to four years before clinical signs appear, potentially improving patient selection for clinical … Read more
Researchers at the University of Pennsylvania have identified a new class of potential antibiotics hidden within prions, the misfolded proteins typically associated with fatal neurodegenerative conditions. By using the deep-learning platform APEX 1.1 to scan 19.3 million protein fragments, the team discovered 1,179 antimicrobial candidates—dubbed “prionins”—that can kill drug-resistant bacteria, according to findings published in … Read more
Beyond “Quality” and “Terrible” Cholesterol: The New Frontier of Lipid Genetics For decades, the conversation around blood lipids has been dominated by a simple binary: “good” HDL cholesterol and “bad” LDL cholesterol. However, the biological reality is far more complex. We are now entering an era where science views lipids not just as markers of … Read more
Redefining the “Golden Hour” in Stroke Recovery For decades, the medical community has operated under a strict “golden hour” philosophy. In the event of an ischemic stroke, the window to administer thrombolytic agents and prevent permanent brain damage is incredibly narrow—typically just a few hours. Once that window closes, the damage was largely considered irreversible. … Read more
Unlocking Alzheimer’s Secrets: AI and CRISPR Lead the Charge Gladstone Institutes investigator Ryan Corces, PhD, has been awarded a prestigious 2026 MIND Prize from the Pershing Square Foundation. The $750,000 grant, distributed over three years, will fuel groundbreaking research into the genetic underpinnings of Alzheimer’s disease, a condition impacting millions globally. The Challenge of “Familial” … Read more
Could a Common Weed Be the Key to Fighting Alzheimer’s? Dandelion Shows Promise A surprising ally in the fight against neurodegenerative diseases like Alzheimer’s may be growing in your backyard. New research suggests that dandelion – often dismissed as a pesky weed – contains compounds that could protect brain health. Specifically, polyphenols found in dandelion … Read more
Unlocking the Brain’s Hidden Role in Alzheimer’s: A Recent Focus on Microglia Researchers are increasingly focused on the brain’s own immune cells, called microglia, and their surprising connection to the progression of Alzheimer’s disease. A recent $402,500 grant awarded to Dr. Sarah C. Hopp of UT Health San Antonio’s Glenn Biggs Institute for Alzheimer’s and … Read more
Air Pollution and Neurodegenerative Disease: A Looming Public Health Crisis New research from the Karolinska Institutet in Sweden adds to a growing body of evidence linking air pollution to an increased risk of motor neuron diseases (MNDs), including Amyotrophic Lateral Sclerosis (ALS). The study, published in JAMA Neurology, reveals a concerning correlation – even at … Read more