Platinum-based chemotherapy drugs cause extensive DNA damage in healthy tissues and accelerate cellular aging in pediatric cancer patients, according to a landmark study published September 10 in Science. Researchers from the Wellcome Sanger Institute, the University of Cambridge, the Francis Crick Institute, and King’s College London used advanced genomic sequencing to analyze samples from children … Read more
River-type drinking water sources generally carry higher threats involving antibiotics, resistant bacteria, and associated genes compared to reservoir options, based on research featured in Biocontaminant. Researchers investigated 13 representative water sources across the Poyang Lake basin, highlighting the importance of considering water source type when designing monitoring and pollution-control strategies. Water Source Types and Contamination … Read more
Researchers at the University of Geneva have successfully restored the defective respiratory protective barrier in cystic fibrosis patients, tackling a primary driver of chronic bacterial infections in one of Switzerland’s most common genetic diseases. According to a study published in the journal Communications Biology, scientists traced the core dysfunction to the abnormal activation of a … Read more
According to a nationwide study published in The Journal of Clinical Investigation, autoimmune diseases do not share a single common genetic vulnerability, but instead form distinct genetic clusters that reflect the specific tissues and organs they affect. Researchers from Karolinska Institutet and collaborating institutions analyzed Swedish national health registers covering more than 6.3 million individuals … Read more
Lifestyle factors like an unhealthy diet can worsen the effects of genetic causes of male infertility, according to a proof-of-concept study published in Human Reproduction. Led by Dr Jessica Dunleavy and Professor Moira O’Bryan from the University of Melbourne’s School of BioSciences, the research used a mouse model carrying defects in the M1AP gene to … Read more
Researchers at Ludwig Princeton have discovered that tumors can manipulate distant organs to evade the immune system, according to a study published in Cell Metabolism. Led by Yibin Kang and Yong Tang, the research demonstrates how cancer cells send signals across the body to alter fat metabolism in the liver and immune responses in CD8⁺ … Read more
According to researchers at ETH, repetitive DNA sequences previously dismissed as useless “junk DNA” actually function as a biological barcode system that helps chromosomes find each other during cell division. Lead author Lena Skrutl and Professor Madhav Jagannathan published these findings in the journal Nature Communications, demonstrating that unique satellite DNA patterns on matching chromosome … Read more
Accelerated biological age (ABA) in midlife serves as a significant predictor for cardiovascular disease, dementia, and mortality, according to a longitudinal study published in Scientific Reports. Researchers analyzing nearly three decades of data from the Framingham Offspring Study found that individuals with a higher biological age than their chronological age faced elevated risks of these … Read more
Broken String Biosciences has launched BaseMap ABE, a new platform designed to identify unintended off-target editing events in adenine base editing (ABE) applications. According to the company and reporting from OneNucleus, the tool uses INDUCE-seq technology to generate genome-wide data directly from biologically relevant cells rather than relying on prediction-based models. How BaseMap ABE Tracks … Read more
Emami and colleagues, the MYH9 gene is emerging as a central player in both cancer biology and inherited genetic conditions, offering fresh perspectives on precision medicine and targeted therapeutics. MYH9 Gene Structure and Core Cellular Functions The MYH9 gene dictates the production of non-muscle myosin IIA, known structurally and functionally as NMIIA. Did you know? … Read more