Scorpion venom peptides are emerging as targeted drug candidates for inflammatory pathways and hepatitis viruses, according to a recent review published in the journal iLIVER. Researchers summarized how these molecules, sourced from over 2,700 documented scorpion species, target receptor proteins and voltage-gated ion channels to treat chronic inflammatory and hepatic disorders without the broad toxicity … Read more
Millions of patients taking glucagon-like peptide-1 receptor agonists (GLP-1RAs) for type 2 diabetes and obesity face renewed clarity regarding psychiatric safety, according to a systematic review published in the journal Cureus by Quadir et al. Researchers evaluating 11 primary studies representing over 4.9 million patients found no consistent class-wide increase in neuropsychiatric risks such as … Read more
According to researchers at the Institute for Basic Science (IBS), a misplaced molecular switch called ERBB4 acts as an early driver of multiple Alzheimer’s disease pathologies in mouse models, triggering neuronal hyperactivity, synapse loss, reactive gliosis, amyloid accumulation, and cognitive impairment when it turns on in excitatory neurons instead of inhibitory neurons. How Misplaced ERBB4 … Read more
Rare CD4 cytotoxic T lymphocytes reach strikingly high levels in people who live beyond 110, revealing an unusual pattern of clonal expansion and functional flexibility, according to a study published in the journal Cell Reports. Researchers characterising these immune cells found that supercentenarians maintain immune profiles that exhibit advanced differentiation without the typical markers of … Read more
According to research published in EMBO Molecular Medicine by teams at Adelaide University and the Olivia Newton-John Cancer Research Institute, a molecular switch driven by low levels of the naturally occurring molecule miR-342 and high activity of the E2F pathway fosters metastatic triple-negative breast cancer. While this aggressive subtype accounts for 10 to 15 percent … Read more
Advanced wastewater treatment technologies designed to remove pathogens and pollutants can inadvertently create unexpected environmental risks by generating toxic transformation products, according to a study published in Energy & Environment Nexus. Researchers evaluating systems at a treatment facility in Tianjin, China, found that ultraviolet irradiation and ozonation processes increased anti-androgenic activity in treated water beyond … Read more
According to research published in the Chinese Medical Journal, a mitochondrial matrix protein known as RTN4IP1 drives the progression and metastasis of triple-negative breast cancer by disrupting cellular energy metabolism. Triple-negative breast cancer accounts for roughly 15% of all breast cases and lacks estrogen, progesterone, and HER2 receptors, leaving patients with high risks of recurrence … Read more
According to a study published on August 7, 2026, in Volume 17 of Oncotarget, treatment with the multi-kinase inhibitor K252a transiently delayed the growth of SK-ES-1 Ewing sarcoma tumor xenografts in immunodeficient mice. Led by researchers at the Federal University of Rio Grande do Sul and INCT BioOncoPed in Brazil, the team found that the … Read more
Human populations living today share a specific genetic legacy from ancient interbreeding events, according to a study led by researchers Hugo Zeberg of Karolinska Institutet and Philipp Kanis of the Max Planck Institute for Evolutionary Anthropology. Modern humans inherited a variant of the growth hormone receptor through interbreeding with Neandertals around 47,000 years ago, resulting … Read more
Liraglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA), triggers rapid but largely reversible shifts in the gut microbiome of obese mice, according to a study published in the journal Microbiology Spectrum. Researchers found that while the drug alters bacterial community structure during active treatment, these changes largely normalize within seven days of discontinuing the medication. … Read more