Researchers at the University of Geneva have successfully restored the defective respiratory protective barrier in cystic fibrosis patients, tackling a primary driver of chronic bacterial infections in one of Switzerland’s most common genetic diseases. According to a study published in the journal Communications Biology, scientists traced the core dysfunction to the abnormal activation of a … Read more
Researchers have identified a urinary tract bacterium capable of converting the steroid precursor DHEA into testosterone under laboratory conditions, revealing a previously unknown microbial pathway that could impact prostate biology, according to a study supervised by Jason M. Ridlon. The finding does not indicate that the bacterium causes prostate cancer or that the microbial testosterone … Read more
According to a randomized clinical trial published in the journal Cell Metabolism, a very-low-carbohydrate ketogenic diet reduces liver fat and improves insulin sensitivity significantly more than Mediterranean or plant-forward diets when participants achieve a comparable 10% weight loss. Researchers found that dietary macronutrient composition independently alters metabolic responses, yielding a 67% reduction in hepatic triglycerides … Read more
Researchers at Ludwig Princeton have discovered that tumors can manipulate distant organs to evade the immune system, according to a study published in Cell Metabolism. Led by Yibin Kang and Yong Tang, the research demonstrates how cancer cells send signals across the body to alter fat metabolism in the liver and immune responses in CD8⁺ … Read more
According to a narrative review published in the journal Nutrients by researchers in Australia and Croatia, the long-debated J-shaped association between moderate wine consumption and lower all-cause mortality remains biologically plausible, though methodological differences heavily shape contemporary public health guidelines. Stockley, Arthur C. Ellison, and Mirela Boban synthesized studies published primarily between 1980 and March … Read more
According to research published in the Chinese Medical Journal, a mitochondrial matrix protein known as RTN4IP1 drives the progression and metastasis of triple-negative breast cancer by disrupting cellular energy metabolism. Triple-negative breast cancer accounts for roughly 15% of all breast cases and lacks estrogen, progesterone, and HER2 receptors, leaving patients with high risks of recurrence … Read more
Researchers at Trinity College Dublin and St. James’s Hospital have demonstrated that dexamethasone, a commonly prescribed anti-inflammatory steroid, reduces harmful inflammation triggered by Mycobacterium avium without weakening the ability of human immune cells to control the infection, according to a study published in the Journal of Infectious Diseases. Understanding Nontuberculous Mycobacterial Disease and Treatment Challenges … Read more
According to researchers at McMaster University, the naturally occurring hormone GDF15 protects the liver from inflammation and slows the progression of scarring through a brain-to-liver signaling pathway independent of weight loss. Published in Cell Metabolism, the findings challenge longstanding assumptions about the hormone, which is best known for suppressing appetite and promoting weight loss. Understanding … Read more
According to researchers led by Sa Kan Yoo at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan, gut cell turnover in fruit flies is governed by the volume and viscosity of food rather than specific nutrient signaling pathways. Published in the Proceedings of the National Academy of Sciences, this discovery challenges traditional nutrient … Read more
People living with well-controlled HIV face an elevated risk of developing type 2 diabetes due to increased scarring in their fat tissues, according to a University of California – San Francisco study published June 30 in JCI Insight. Fat Fibrosis and Insulin Resistance in HIV Researchers at UCSF investigated why patients with suppressed HIV maintain … Read more