Lactylation-driven metabolic reprogramming acts as a central driver of therapeutic resistance in cancer, according to recent findings published in the journal Genes & Diseases by researchers Wanghao Zhang, Guanglong Huang, Woheng Tang, Jiaxian Li, Jingxian Chen, Yaojiang Feng, Kaichen Li, Can Pan, Shunshen Li, Huayang Zhang, Rongxu Ye, Hao Long, and Guo-zhong Yi. This cellular … Read more
Researchers at The University of Texas at Austin have developed an experimental drug that tricks aggressive cancer cells into consuming more sugar than usual while simultaneously blocking their backup fat metabolism. According to a study published in Nature Chemical Biology, the compound successfully treated an aggressive form of melanoma in mice by attacking both cellular … Read more
Daily consumption of raw tomatoes and tomato sauce significantly reduces controlled attenuation parameter (CAP)-defined hepatic steatosis in adults with metabolic dysfunction-associated steatotic liver disease (MASLD), according to an exploratory randomized controlled trial published in the journal Nutrients. Researchers found that a six-week tomato-rich diet outperformed a tomato-free control group, dropping median CAP values by 35 … Read more
According to a narrative review published in the journal Nutrients by researchers at the University of Guelph and ImmunoCeutica Inc., iodine intake follows a narrow U-shaped relationship that dictates how the micronutrient influences immune defenses across humans and domesticated mammals. While adequate intake supports leukocyte metabolism and thyroid-driven immunity, both chronic deficiency and sustained excess … Read more
Epigenetic clocks—tools designed to measure biological age through DNA methylation—capture distinct, non-overlapping biological processes rather than a single universal aging mechanism. According to a study published in npj Aging, researchers have developed Transcriptomic Aging Gene Scores (TAGS) to better interpret these clocks, showing that gene expression patterns often predict health outcomes like mortality and frailty … Read more
A recent cross-sectional study published in the journal Nutrients found no statistically significant link between an individual’s chronotype—their natural preference for morning or evening activity—and the presence of liver fat or fibrosis in adults with overweight or obesity. Researchers at the National Institute of Gastroenterology in Italy assessed 119 medication-naïve participants using the Morningness–Eveningness Questionnaire … Read more
Senescent cells—damaged cells that stop dividing but remain metabolically active—accumulate lipid droplets as a hallmark of their aging state, according to a study published July 1, 2026, in the journal Aging. Researchers led by Noa Rachmian-Cooper and Valery Krizhanovsky at the Weizmann Institute of Science found that these lipid deposits are linked to chronic inflammation … Read more
Healthy women with an evening chronotype—individuals who naturally prefer later sleep and meal times—show higher body fat percentages and less favorable metabolic markers compared to those with morning or intermediate preferences, according to a study published in Frontiers in Nutrition. Research from the PROMISE study indicates that meal timing, particularly the consumption of energy late … Read more
Research from the University of Virginia (UVA) Comprehensive Cancer Center indicates that a buildup of bile acids, triggered by an unhealthy gut microbiome, can drive hormone receptor-positive (HR+) breast cancer to metastasize to other organs, particularly the lungs. According to Melanie Rutkowski, PhD, this mechanism suggests that FDA-approved bile acid sequestrants or microbiome replenishment could … Read more
Lactoferrin-fortified yogurt maintains ferritin levels in pregnant women with gestational diabetes mellitus (GDM) without causing iron overload, according to a randomized trial published in npj Science of Food. The study found that 100 mg of bovine lactoferrin per serving helped stabilize iron stores in women with reduced ferritin, offering a well-tolerated alternative to relying solely … Read more