Research from the University of Virginia (UVA) Comprehensive Cancer Center indicates that a buildup of bile acids, triggered by an unhealthy gut microbiome, can drive hormone receptor-positive (HR+) breast cancer to metastasize to other organs, particularly the lungs. According to Melanie Rutkowski, PhD, this mechanism suggests that FDA-approved bile acid sequestrants or microbiome replenishment could … Read more
The U.S. Food and Drug Administration approved zenocutuzumab as a second-line therapy for NRG1-positive cholangiocarcinoma on May 8. According to results from the eNRGy phase 2 clinical trial published in the Journal of Clinical Oncology, the drug more than doubled the median progression-free survival to 9.2 months, compared to the approximately four months typically seen … Read more
MIT engineers have developed a novel, gel-based drug delivery system designed to coat the esophageal lining and transport medication directly into the tissue. By utilizing a hydrogel combined with permeability-enhancing bile salts, this approach aims to treat disorders like eosinophilic esophagitis and Crohn’s disease while avoiding the systemic side effects of traditional immunosuppressant drugs, according … Read more
New research presented at ASM Microbe 2026 identifies a critical link between gut microbes, bile acids, and cardiovascular complications in sleep apnea patients. According to the American Society for Microbiology, targeting the farnesoid X receptor (FXR) may offer a new path for preventing heart and metabolic damage caused by the disorder, which affects millions worldwide. … Read more
The Future of Bariatric Recovery: Why Geometry Is the New Frontier in Medical Devices Every year, a quarter-million Americans undergo sleeve gastrectomy—a life-changing procedure that offers a fresh start for those struggling with obesity. Yet, for a small percentage of patients, the road to recovery hits a wall. Gastric leaks, where fluid escapes from the … Read more