Researchers at the Walter and Eliza Hall Institute (WEHI) in Melbourne, Australia, have developed a new vaccination approach that uses antimalarial drug compounds to transform mosquito bites from a source of deadly infection into natural immune boosters, according to a study published in Science. Targeting the Late Liver Stage to Build Durable Immunity The preclinical … Read more
Immunosuppressed patients diagnosed with non-melanoma skin cancer are not lacking vital cancer-fighting immune cells as previously believed, but rather possess macrophages that have lost their ability to communicate effectively, according to a study published in Cell by researchers at The University of Texas MD Anderson Cancer Center. The findings reveal that macrophages in patients with … Read more
According to a study published in BMC Biology, researchers at the USC Dornsife College of Letters, Arts and Sciences and Howard University have discovered that modern human immune responses bear genetic marks of ancient battles with infectious diseases, while also identifying rare variants linked to severe COVID-19. The findings bridge human evolution and infectious disease. … Read more
New research published in the journal Cell reveals that severe COVID-19 cases are often linked to a pre-existing immune defect where the body produces autoantibodies that neutralize type I interferons. According to findings from an international team of scientists, these autoantibodies are the result of a mature B-cell response that disables the body’s primary antiviral … Read more
Orthonairoviruses, a family of tick-borne pathogens, can bypass human immune defenses using specialized proteins called ovarian tumor domain proteases (OTUs), according to a study led by University of California, Riverside (UCR). This mechanism allows viruses like the Crimean-Congo hemorrhagic fever virus to suppress the body’s ability to detect and fight infection, increasing pandemic risk. How … Read more
New research from University College London (UCL) and Great Ormond Street Hospital (GOSH) indicates that effective respiratory syncytial virus (RSV) treatments for infants must target both the virus and the host’s immune response. Published in Nature Communications, the study utilized a novel lab-grown model of infant airways to demonstrate that the pediatric immune system triggers … Read more
Researchers from the Department of Breast Surgery at Fudan University Shanghai Cancer Center and the Department of Oncology at Shanghai Medical College, Fudan University have developed a new classification system for breast cancer based on the cancer-immunity cycle (CIC). Published in Cancer Biology & Medicine in 2026, this framework uses a “CIC score” to categorize … Read more
Researchers at the RCSI University of Medicine and Health Sciences have developed a novel mRNA vaccine for neuroblastoma using self-assembling peptide nanoparticles. According to study lead Olga Piskareva, the vaccine, which targets the glypican 2 (GPC2) antigen, reduced tumor volume by 70% in murine models. This approach offers a potential alternative to traditional lipid-based delivery … Read more
The End of “Reactive” Medicine: How AI is Ending the Pandemic Chase For decades, humanity has played a high-stakes game of cat-and-mouse with viruses. When a new pathogen emerges, scientists rush to sequence it, manufacture a targeted vaccine, and scramble to distribute it—often just as the virus begins to mutate into something new. We see … Read more
The Neuroimmune Frontier: Redefining How We Fight Lung Cancer For decades, the battle against lung cancer has focused primarily on two fronts: attacking the tumor directly and boosting the immune system to recognize and destroy malignant cells. However, a groundbreaking discovery from the Francis Crick Institute suggests we have been missing a critical piece of … Read more