Prime assembly, a novel genome engineering method leveraging CRISPR-targeted dual flap synthesis, allows long DNA fragments to be integrated into precise and programmable target positions within living cells, according to a paper published in Nature. Developed to overcome the limitations of untargeted gene delivery and short DNA edits that require individualization for each patient, the … Read more
A newly proposed International Association for the Study of Lung Cancer tumor budding-based grading system can identify resected lung squamous cell carcinoma patients at higher risk of poor outcomes and helps guide adjuvant chemotherapy selection, according to research presented by T.H. Hong at the IASLC World Conference on Lung Cancer, as reported by Mirage News … Read more
Researchers at Johns Hopkins Medicine have developed CloudScope, a cloud-based miniaturized microscope that enables continuous neurosurveillance of brain activity, blood flow, oxygenation, and cellular dynamics in freely moving mouse models for more than 24 hours. According to Arvind Pathak, professor of radiology, oncology, and biomedical and electrical engineering at Johns Hopkins, the innovation addresses a … Read more
According to researchers at McMaster University, a team combining chemistry, structural biology, and transfusion medicine has uncovered the precise molecular mechanism driving heparin-induced thrombocytopenia (HIT), a rare and potentially life-threatening immune reaction to the common blood thinner heparin. Published on September 11, 2026, in Nature Communications, the study identifies a structural switch within platelet factor … Read more
Genomic newborn screening using heel-stick blood spots can identify infants at high risk for early-onset cancers before symptoms appear, according to a Nature Communications study led by researchers from Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Mass General Brigham, and collaborators. Analyzing archived samples from 1,948 children in Michigan who developed solid or central nervous … Read more
Preclinical studies published in PNAS show that supercharged bifunctional antisense oligonucleotides efficiently skip mutated exons and restore dystrophin expression in Duchenne muscular dystrophy models, according to findings from Nanjing Antisense Biopharm researcher Pengchao Feng and his team. Bipartite Antisense Oligonucleotides Target Duchenne Muscular Dystrophy Duchenne muscular dystrophy is an X-linked recessive progressive muscle condition primarily … Read more
Candida auris causes roughly 3,000 deaths each year among patients in U.S. hospitals and long-term care facilities, according to federal health data, prompting researchers to investigate how this multidrug-resistant pathogenic yeast persists on human skin. While the fungus has been known to colonize the skin since its discovery in 2009, scientists have lacked a clear … Read more
Astrin Biosciences is expanding physician outreach and preparing a direct-to-consumer launch for Certitude, a proteomic-based breast cancer diagnostic test that leverages mass spectrometry and machine learning. According to the company, the test identifies high-risk patients and detects early-stage malignancies from a small plasma sample. How Proteomics and AI Outperform Traditional DNA Liquid Biopsies in Early … Read more
Outlined in Nature Materials, the advanced biomaterial uses aptamer constructs to selectively harvest and concentrate endogenous healing substances, offering a potential breakthrough for patients with acute and chronic wounds that fail to heal on their own. How Biomaterial Scaffolds Target Chronic Wounds Millions of people worldwide suffer from hard-to-heal wounds like large burns, diabetic foot … Read more
New data from a National Institutes of Health-funded study reveals that midlife brings substantial remodeling to the immune cell landscape of the human hippocampus, pointing to a potential mechanism behind chronic neuroinflammation in neurodegenerative diseases. Scientists analyzed postmortem hippocampal tissue from 40 neurologically healthy adults aged 20 to 95 years old, as detailed in a … Read more