drug discovery

Saussurea costus and Doxorubicin Suppress Breast Cancer Cell Migration and Proliferation

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Saussurea costus and Doxorubicin Suppress Breast Cancer Cell Migration and Proliferation

Saussurea costus root extract contains 28 tentatively identified compounds, including flavonoids, phenolics, and sesquiterpenes, as detailed in an LC–ESI–MS/MS investigation published in Nature. The major constituents by peak area are apigenin at 12.99%, medioresinol at 8.32%, luteolin at 8.32%, rhoifolin at 7.34%, luteolin-7-O-glucoside at 7.13%, and cirsimaritin at 6.75%. Previously undetected compounds in the root … Read more

Scientists map mitochondrial proteins across six eukaryotic organisms

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Scientists map mitochondrial proteins across six eukaryotic organisms

Mapping the Eukaryotic Mitoproteome Scientists have mapped the proteins that make up mitochondria in six different organisms across the eukaryotic tree of life, uncovering dozens of proteins shared among parasites that are absent in humans. The findings, published across nine papers in journals including Cell and Molecular Cell, provide a dynamic picture of the organelle … Read more

Protein Sciences in Drug Discovery 2026 Reveals Keynote Speakers

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Protein Sciences in Drug Discovery 2026 Reveals Keynote Speakers

Prof Dame Carol Robinson, Dr Andrew Doré, and Prof Paula Booth will headline the Protein Sciences in Drug Discovery 2026 conference. The volunteer-led organization ELRIG and The Protein Society announced the keynote lineup for the upcoming event, which runs from 10–11 November 2026 at GSK Stevenage. Keynote Speakers at GSK Stevenage The free-to-attend event connects … Read more

AI & Proteomics Drive Breakthroughs in VAV1 Molecular Glue Discovery

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Researchers at Baylor College of Medicine have combined high-throughput proteomics with artificial intelligence to discover and optimize molecular glues that target VAV1, an immune-cell signaling protein linked to blood cancers and autoimmune diseases. Published in Nature Communications, the study details how the workflow—dubbed GluePlex—accelerates the identification of compounds that direct the cell’s disposal machinery to … Read more

Tautomer-Predictor AI: Accelerating Stable Molecule Drug Discovery

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New York University researchers have trained an artificial intelligence model to predict precise hydrogen atom positions in drug-like molecules, tackling a persistent hurdle in molecular design according to a study published in Chemical Science. Led by NYU chemistry professor Yingkai Zhang, the team developed an open-source tool called Tautomer-Predictor to rapidly evaluate stability patterns across … Read more

AI Co-Scientists: Revolutionizing Modern Research

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Biochemist Anna Pertl typed her prompt into Google’s Co-Scientist AI system on a rainy Tuesday in July and left the laboratory for the night, letting autonomous agents search hundreds of papers to tackle MYC, a protein that runs amok in most cancers and has long defied attack attempts. Advanced AI research assistants are transforming how … Read more

Scorpion Venom for Liver Disease: Can It Inspire New Treatments?

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Scorpion venom peptides are emerging as targeted drug candidates for inflammatory pathways and hepatitis viruses, according to a recent review published in the journal iLIVER. Researchers summarized how these molecules, sourced from over 2,700 documented scorpion species, target receptor proteins and voltage-gated ion channels to treat chronic inflammatory and hepatic disorders without the broad toxicity … Read more

AI-Powered Target Discovery for Rare Sinonasal Cancer by Insilico Medicine

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Insilico Medicine published a collaborative study in the journal npj Precision Oncology, detailing how artificial intelligence and multi-omic analysis identified therapeutic targets in inverted papilloma-associated sinonasal squamous cell carcinoma (IP-SNSCC), a rare head and neck cancer. Conducted with researchers from the University of Chicago and Johns Hopkins University, the peer-reviewed paper offers the first comprehensive … Read more

Viagra Ingredient Stops Cancer Spread in World First Study

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< div> According to peer-reviewed research published in July in Cancer Research, sildenafil—the active ingredient in Viagra—disrupts cancer cells’ cholesterol supply to stop the spread of metastases. Researchers at the Weizmann Institute of Science, alongside teams from the US National Cancer Institute and Clalit Health Services, found that the drug targets the protein transporting essential … Read more

Patient-Derived Organoids for Chronic Pancreatitis Therapy

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Researchers at the Salk Institute have developed a patient-derived organoid platform to study chronic pancreatitis, a condition affecting approximately three million people worldwide for which no cure currently exists. By generating 37 organoids from patients, the study—published in Cell Stem Cell—identified cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction as a key therapeutic target and uncovered … Read more

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