scientists from Brazil claimed to have a medicine capable of stopping COVID-19

Experts from the Fiocruz Development Center analyzed Atazanavir, a drug used against HIV that could be effective against coronavirus.

A group of Brazilian scientists from the center Fiocruz could have found a medicine against coronavirus. This is Atazanavir, a remedy used to treat HIV-infected patients.

This medicine has an anti-inflammatory function, since it helps to reduce the inflammatory process in the lungs. According to recent research, the drug may inhibit viral replication of SARS-CoV-2.

Recall that this center is located in Brazil and is currently one of the largest medical research centers in Latin America, working directly with the government of that country.

Coronavirus: Brazilian scientists claimed to have a medicine capable of stopping COVID-19

Coronavirus and Brazil

As a result of the investigations and monitoring that has been done to the virus, the experts noticed several characteristics. One of the first is that Atazanavir is able to stop the multiplication of the coronavirus in the body.

This would be achieved thanks to its anti-inflammatory capacity, which is why it is used to face AIDS.

As Atazanavir was exposed to the SARS-CoV-2 spike protein, it showed a positive reaction. According to a statement delivered by the Institution, the drug managed to “reduce the proteins that are linked to the inflammatory process in the lungs.”

Coronavirus: Brazilian scientists claimed to have a medicine capable of stopping COVID-19

The direct intervention of the drug can affect the reduction of the serious clinical picture generated by the coronavirus. Although the investigation is still preliminary, it may be a door for a possible drug to face the pandemic.

In the words of Thiago Moreno, Fiocruz researcher and one of the project coordinators, “Testing for drugs already approved for other uses is the fastest strategy that science can offer to combat COVID-19.”. For his part, the expert also emphasized that social distancing is also another essential measure.

For their part, experts will continue studies to analyze the long-term effectiveness of the drug. It is hoped that the utility may increase with the combined use of Ritonavir and Atazanavir, which are targeted medicines to treat AIDS.

Coronavirus: Brazilian scientists claimed to have a medicine capable of stopping COVID-19

Possible medication for the disease

Researchers at the Center for Technological Development in Health believe they have found a more effective mediation than Chloroquine. According to them, Atazanavir causes better bioavailability in the respiratory tract. This situation can be transcendental in the fight against SARS-CoV-2 and its reproduction.

This means that the drug manages to occupy the cleft of the active substrate during molecular analyzes. With this, it could block the advance of the virus.

Coronavirus: Brazilian scientists claimed to have a medicine capable of stopping COVID-19

The researchers will continue to test the reaction through various cell types using in vitro assays. Those that will be dealt with will be the following:

  • Lung cell
  • Human epithelial cell
  • Human primary monocytes

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COVID-19: Pharmaceutical company announces that medicine for the disease is ready

The Spanish pharmaceutical company PharmaMar has reported that all the results obtained through in vitro examinations for its clinical study of the drug Aplidin (possible drug for the coronavirus) have been positive.

According to the research group, the potency that Aplidin has shown in its effectiveness is a nanomolar order. So it is possible that this will help reverse the symptoms that the coronavirus.

Medication use

This type of medication is frequently used for the treatment of Hematological Cancer, being approved in several countries, such as Australia, Taiwan, New Zealand and South Korea.

Most of the studies carried out for this medicine have been carried out at the National Center for Biotechnology of the Superior Center for Scientific Research. There, several experts have devoted themselves to seeing the effectiveness of the medicine against the disease.

Among the results obtained, it has been possible to verify a hypothesis in which it is proposed that the therapeutic target of this antitumor drug called Aplidin. This has had a key response for the multiplication and spread of the virus itself.

The protein that causes this situation is known as EF1A, essential for the virus to expand within the human body.

Function

This process is known as nucleoprotein, where the virus manages to become visible and also manages to reproduce, finally spreading through the cells of the body. The role it would fulfill Aplidin it would be to hijack the virus, forming a resistance (stable complex) that would cause the virus to be unable to spread and be viable in the body.

Human testing?

Thanks to these results, the PharmaMar pharmacist will carry out all the subsequent steps in order to contact the health authorities. Thus begin to carry out tests on human patients infected with the disease, to check how they behave.

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