Gene

Early Detection of Congenital Ventriculomegaly: Preventing Developmental Disabilities

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New research published in Science Translational Medicine indicates that congenital cerebral ventriculomegaly (CCV)—a condition marked by fluid-filled brain ventricle swelling—is frequently linked to rare, damaging gene mutations. According to investigators at the Mass General Brigham Neuroscience Institute, these genetic findings suggest that CCV is often a marker of underlying neurodevelopmental disorders, including autism spectrum disorder, … Read more

AI Reveals Hidden Molecular Signals Boosting Thrombosis Risk

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Researchers from the Sant Pau Research Institute (IR Sant Pau) and CIBERER have developed an AI tool that identifies hundreds of molecular signals to predict venous thrombosis. By integrating clinical, genetic, and transcriptomic data, the system improves risk stratification for idiopathic venous thromboembolism, as detailed in the Journal of Thrombosis and Haemostasis. Why do some … Read more

Biologists Create Synthetic Cell That Evolves, Grows, and Divides

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Biologists at the University of Minnesota have successfully engineered a synthetic cell, dubbed “SpudCell,” capable of performing core biological life cycles including nutrient intake, growth, DNA replication, and division. According to a preprint posted July 2 on bioRxiv, the cell is constructed entirely from non-living chemical components and functions with a 90,000-base-pair genome, significantly smaller … Read more

Targeted Therapy Doubles Survival in Rare Bile Duct Cancer

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The U.S. Food and Drug Administration approved zenocutuzumab as a second-line therapy for NRG1-positive cholangiocarcinoma on May 8. According to results from the eNRGy phase 2 clinical trial published in the Journal of Clinical Oncology, the drug more than doubled the median progression-free survival to 9.2 months, compared to the approximately four months typically seen … Read more

New Screening Method Identifies Proteins Controlling Human Gene Expression

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Researchers have identified 63 high-confidence activators of poly(A) site usage, a critical process in gene expression. Led by Gene Yeo of UC San Diego and Yongsheng Shi of UC Irvine, the study, published June 26, 2026, in Molecular Cell, provides a new programmable framework for manipulating RNA processing in human cells. How do these newly … Read more

Neanderthals in Northwestern Europe: New Ancient DNA Insights

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Researchers have recovered genetic data from 27 Neanderthals in Belgium and France, revealing that these late populations maintained regional connectivity rather than living in isolated, inbred groups. According to a study published in Nature by Alba Bossoms Mesa and colleagues at the Max Planck Institute for Evolutionary Anthropology, these findings challenge the theory that genetic … Read more

High-Dose DHA Fails to Boost Memory Despite Brain Penetration

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High-dose docosahexaenoic acid (DHA) supplementation successfully increases omega-3 levels in the human brain but fails to halt cognitive decline or structural brain changes, according to a randomized clinical trial published in eBioMedicine. Researchers monitored 365 older adults over two years, finding that while the supplement reached the central nervous system, it provided no measurable benefit … Read more

New Molecular Pathway Linked to Delayed Diabetic Wound Healing

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Researchers have identified the ILF2 protein as a critical regulator of diabetic wound healing, acting as a molecular brake that prevents the cellular senescence responsible for chronic diabetic foot ulcers (DFU). According to a study published March 17, 2026, in the journal Burns & Trauma, the loss of ILF2 leads to the accumulation of NPM1 … Read more

How Psychological Traits Influence Alzheimer’s Biology

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Long-standing psychological traits, including neuroticism and a lack of purpose, track distinct molecular pathways in Alzheimer’s dementia, according to a multi-omics study published in Translational Psychiatry. Researchers from the Religious Orders Study (ROS) and the Rush Memory and Aging Project (MAP) found that while traditional pathology and genetic risk factors identify overall disease susceptibility, these … Read more

How a Fading Protein Drives Heart Aging

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Researchers have identified a decline in the PRDM16 protein as a primary driver of cardiac aging, according to a study published in Science Advances. By analyzing 442,239 single nuclei from human heart tissue, the team mapped how cellular balance shifts from fetal development through age 75. Restoring PRDM16 levels in aged mouse models improved heart … Read more

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