Molecular Medicine

High-fat diet and chronic restraint stress exacerbate anxiety-depressive behaviors via astrocytic A1 phenotype transformation

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The Rising Impact of HFD and CRS on Mental Health The interplay between high-fat diets (HFD) and chronic restraint stress (CRS) is increasingly recognized as a significant contributor to mental health disorders. Research has shown that these factors can lead to depression-like and anxiety behaviors in mice, highlighting a potential pathway to understanding similar effects … Read more

Functional verification and allele-specific silencing of a novel AKT3 variant that causes megalencephaly, polymicrogyria and intractable epilepsy

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The Evolving Landscape of Genetic Disorders and Modern Therapies Unlocking the Mysteries of Megalencephaly and Related Disorders The link between AKT3 mutations and a spectrum of developmental disorders, including megalencephaly, has opened enormous possibilities for research and therapeutic interventions. Studies like those by Alcantara et al. (2017) highlight how mutations in AKT3 can lead to … Read more

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