AI-Designed Nucleases: Enhancing Nature’s Genetic Tools
Researchers led by Nobel laureate Jennifer Doudna at the Innovative Genomics Institute and the University of California, Berkeley, have successfully used generative AI to design novel RNA-guided nucleases, a breakthrough in synthetic biology. By combining evolutionary data with inverse protein-folding models, the team created "SynTnpBs"—synthetic variants of TnpB proteins—that match or exceed the editing performance … Read more