Structural Basis of RISC Assembly via Chaperones
The Role of Chaperone Machinery in RISC Assembly The assembly of the RNA-induced silencing complex (RISC) depends on the coordinated action of Hsp70 and Hsp90 chaperone systems to load small RNA duplexes into Argonaute proteins. According to research published in Molecular Cell by Iwasaki et al. (2010), this ATP-dependent process is essential for activating the … Read more