A sports betting analyst reported a 38-26-0 straight-up record contrasted against a 25-37-2 against-the-spread record for the season following a 9-7 straight-up and 4-11-1 ATS performance last week. Late-game back-door covers damaged the point-spread results, prompting an immediate push to reach .500 for the upcoming slate of matchups spanning Thursday night through Monday night.
Tampa Bay Buccaneers Face Dallas Cowboys on Thursday Night
The Tampa Bay Buccaneers sit at 0-4 and are starting rookie quarterback Jalon Daniels on his first road start during a Thursday night contest. The Dallas Cowboys enter the matchup at 8:15 p.m. on Amazon Prime following a dynamic offensive victory at Houston. A projected final score is Cowboys 34, Buccaneers 14, laying 9.5 points on DraftKings lines.
Philadelphia Eagles Travel to Jacksonville for London Showdown
The Philadelphia Eagles are dealing with major injuries and the retirement of right tackle Lane Johnson on Tuesday following a loss to the Rams. The Jacksonville Jaguars rank second in scoring defense and have successfully stopped the run all season. The Sunday 9:30 a.m. matchup on NFL Network features Jacksonville as 7-point favorites in a projected 28-16 victory.
Chicago Bears Visit Green Bay Packers Without Caleb Williams
The Chicago Bears play without Caleb Williams against a Green Bay Packers team favored by 3 points at home on Sunday at 1 p.m. on Fox. Jordan Love aims for a productive throwing performance to secure an upset win for Green Bay. The final pick is listed as Packers 27, Bears 24.
Houston Texans Meet Tennessee Titans in Battle of Winless Teams
Both the Houston Texans and Tennessee Titans hold 0-4 records entering their Sunday meeting. The Titans have played multiple close contests, but C.J. Stroud is projected to make late plays for a 23-17 Texans victory as 7-point favorites.
Cincinnati Bengals Play Miami Dolphins Despite Receiver Injuries
The Cincinnati Bengals face the Miami Dolphins at 1 p.m. on Fox while managing injuries to wide receivers Tee Higgins and Ja’Marr Chase from the previous week against Jacksonville. Even if the receivers miss time, Cincinnati is favored by 7 points in a projected 23-13 win over an undermanned Miami squad.
Las Vegas Raiders Travel to Face New England Patriots
The Las Vegas Raiders face a long road trip following a division loss, while the New England Patriots look to build on Drake Maye’s strong performance against the Buffalo Bills. The Patriots are 3.5-point favorites at home in a game projected 28-24 for New England.
Minnesota Vikings Play New Orleans Saints on the Road
The New Orleans Saints lost to the Atlanta Falcons on Monday night and now face an undefeated Minnesota Vikings team boasting a standout defense. The Saints are dealing with defensive injuries as Kyler Murray prepares to face them. A projected score is a 24-17 win for the Vikings as 1.5-point favorites.
Cleveland Browns Play New York Jets on Sunday
The Cleveland Browns bring a three-game winning streak and a 3-1 record into New York to face a Jets team that has lost three straight. The Jets return home after two road games, a factor contributing to a projected 20-16 upset victory for New York as 2.5-point underdogs.
Indianapolis Colts Face Pittsburgh Steelers on Short Rest
The Indianapolis Colts travel to face the Pittsburgh Steelers on Sunday after defeating the Washington Commanders in London last week. The Steelers enjoy extra days of rest and enter as 2.5-point favorites. Aaron Rodgers is projected to lead Pittsburgh to a 33-23 victory.

New York Giants Play Washington Commanders on the Road
Jayden Daniels may return for the Washington Commanders while wearing an elbow brace. The 3-1 New York Giants face a major road test as 3-point underdogs, with Jameis Winston projected to lead a 26-24 victory.
Denver Broncos Visit Los Angeles Chargers
The Denver Broncos play consecutive road games following a loss at San Francisco, while the winless Los Angeles Chargers enter desperate for a victory. The Chargers are 3.5-point favorites at home in a projected 23-17 win.
Detroit Lions Play Arizona Cardinals in Arizona
The Detroit Lions play on the road following a Sunday night loss, carrying defensive struggles into a matchup against an Arizona Cardinals team with its own defensive issues. The Lions are favored by 4.5 points in a projected 40-31 high-scoring affair.
San Francisco 49ers Meet Seattle Seahawks in NFC West Clash
The undefeated San Francisco 49ers travel to face the Seattle Seahawks in a physical division rivalry game. The Seahawks are healthier, but San Francisco has played better overall and has played well in Seattle. A projected late defensive stand by Seattle is expected to secure a 28-21 win as 2.5-point underdogs.
Baltimore Ravens Play Atlanta Falcons Without Lamar Jackson
The Baltimore Ravens may play without Lamar Jackson following an ankle injury last week, with Tyler Huntley potentially starting in a run-heavy game featuring Derrick Henry. The Atlanta Falcons are on a short week after defeating New Orleans. A projected score is a 24-17 victory for Baltimore as 2.5-point favorites.
Buffalo Bills Meet Los Angeles Rams on Monday Night
The Buffalo Bills face the Los Angeles Rams on Monday at 8:15 p.m. on ESPN following a loss to New England, while the Rams rallied past Philadelphia. Josh Allen and Matt Stafford headline a matchup projected at 34-33 for the Rams as 2.5-point favorites.
Frequently Asked Questions About NFL Week 5 Matchups
What is the spread and time for the Tampa Bay Buccaneers against the Dallas Cowboys?
The Dallas Cowboys are favored by 9.5 points on DraftKings lines, with kickoff set for Thursday at 8:15 p.m. ET on Amazon Prime.
Which teams are playing in the NFL London game this week?
The Philadelphia Eagles play the Jacksonville Jaguars in London on Sunday at 9:30 a.m. ET on NFL Network, with Jacksonville favored by 7 points.
What are the broadcasting details for the Buffalo Bills and Los Angeles Rams game?
The Buffalo Bills play the Los Angeles Rams on Monday at 8:15 p.m. ET on ESPN, with the Rams listed as 2.5-point favorites.