Headline: Common Virus Linked to Alzheimer’s: A Breakthrough in Understanding the Disease
Subhead: Scientists discover a common virus in the intestines of some Alzheimer’s patients, potentially contributing to the disease’s development.
In a groundbreaking discovery, researchers have found a common virus in the intestines of some Alzheimer’s patients, which could potentially contribute to the development of the disease. The virus, known as Cytomegalovirus (CMV) or Human Herpesvirus 5 (HHV-5), is estimated to infect up to 50% of the population in their first few decades of life, according to reports by The Independent.
CMV, one of the nine herpes viruses to which most people are exposed in their early years, is not typically transmitted sexually, unlike most herpes viruses. However, this virus has been found to persist in the intestines and may travel to the brain via the vagus nerve or through the bloodstream, according to a study published in the journal Alzheimer’s & Dementia.
Once in the brain, the virus may trigger immune system changes associated with Alzheimer’s disease. If validated by further research, existing antiviral medications could potentially be tested to treat or prevent this form of Alzheimer’s, supported by a blood test currently in development.
The virus, upon reaching the brain, activates the expression of a gene called CD83 in immune cells known as microglia. Previous studies have linked CD83 to Alzheimer’s. Microglia, which normally protect the brain, can become overactive and inflame, causing damage to neurons and contributing to Alzheimer’s progression.
A study from last year found higher levels of microglia expressing CD83 in the brains of deceased Alzheimer’s patients compared to healthy individuals. An antibody was also found in the intestines, suggesting an infection may have contributed to this type of Alzheimer’s.
In the latest study, researchers showed that the virus can induce changes associated with Alzheimer’s, such as the production of amyloid proteins and tau, which lead to the death of nerve cells. However, more studies are needed to confirm these theories.
This discovery opens up new avenues for understanding and potentially treating Alzheimer’s disease, a progressive neurodegenerative disorder that affects millions of people worldwide. While more research is needed, the presence of this common virus in the intestines of some Alzheimer’s patients offers a promising new lead in the quest to unravel the complex causes of this devastating condition.
