COVID 19, the department is preparing to be classified in the red zone

HEALTH / Concretely, this means that the virus is actively circulating. New measures are taken

COVID 19, the department of Alpes de Haute-Provence is preparing to be classified in the red zone known as “active circulation of the virus”. Information from the prefecture and ARS Provence Alpes Côte d’Azur this Friday. The incidence rate exceeded the threshold of 50 on September 23, whereas it was 16 on September 7. This rate brings the number of positive cases to 100,000 inhabitants. According to the ARS, only three resuscitation beds remain available in the Department, “hospital tensions are high in the region”. Three clusters were counted, and one “in the town of Sisteron, which follows a wedding and a birthday is particularly active” continues the Regional Health Agency. From Monday, parties, weddings, associative events, communions, etc. will have to be held in small groups, ie less than 30 people. In addition, the wearing of a mask will be compulsory, by prefectural decision, for all people over 11 years old, in the 30-meter zone around all entrances and exits of schools and around bus stops. Obligation also on markets, fairs, garage sales and fairgrounds. Finally, note that the prefect Violaine Démaret asked the mayors “to ensure that the municipal registers are properly updated”. Objective: to allow regular monitoring of vulnerable and precarious people.

A. Vallauri

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update on the Red Devils with our journalist (podcast)

Two days after the start of the Red Devils rally in Tubize, we take stock with our expert Jonas Bernard on the news of the national team. A particular recovery due to the coronavirus crisis, the condition of the players, the absence of Kevin De Bruyne: discover our podcast analysis.


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Covid 19, nine people hospitalized in our departments

HEALTH / Since the start of the epidemic, 22,591 people have tested positive for the Covid-19 coronavirus in the PACA region

Coronarivus: despite the holidays, the” Provence-Alpes-Côte d’Azur Regional Health Agency always calls for vigilance in the face of the epidemic. According to the latest figures published on Tuesday, 344 people are currently hospitalized in our region, including 16 placed in intensive care. Since the start of the epidemic, 974 hospitalized people have died, including four last week, and 22,591 people tested positive, including 1,137 more people compared to the last report on August 11.

In the Hautes-Alpes

According to figures from the ARS, five people are hospitalized. This is one more than the previous week. One patient was placed in intensive care. Since the start of the epidemic, 18 people have died in the department and 135 have returned home. Regarding nursing homes, 25 residents have tested positive for Covid-19, 22 are hospitalized. The Regional Health Agency notes 10 deaths among residents of the Hautes-Alpes, including one in a retirement home and nine in the hospital. The incidence rate is 14.1 (14.1 cases per 100,000 inhabitants).

In the Alpes de Haute-Provence

According to figures from the ARS, four people are hospitalized. No patient is placed in intensive care. Since the start of the epidemic, 13 people have died in the department and 133 have returned home. Regarding nursing homes, 24 residents have tested positive for Covid-19, 8 are hospitalized. The Regional Health Agency notes five deaths among residents of the Lower Alps, all in retirement homes. The incidence rate is 28.5 (28.5 cases per 100,000 inhabitants).

C. Cava Michard

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Covid 19, nine people hospitalized in our departments

HEALTH / Since the start of the epidemic, 22,591 people have tested positive for the Covid-19 coronavirus in the PACA region

Coronarivus: despite the holidays, the” Provence-Alpes-Côte d’Azur Regional Health Agency always calls for vigilance in the face of the epidemic. According to the latest figures published on Tuesday, 344 people are currently hospitalized in our region, including 16 placed in intensive care. Since the start of the epidemic, 974 hospitalized people have died, including four last week, and 22,591 people tested positive, including 1,137 more people compared to the last report on August 11.

In the Hautes-Alpes

According to figures from the ARS, five people are hospitalized. This is one more than the previous week. One patient was placed in intensive care. Since the start of the epidemic, 18 people have died in the department and 135 have returned home. Regarding nursing homes, 25 residents have tested positive for Covid-19, 22 are hospitalized. The Regional Health Agency notes 10 deaths among residents of the Hautes-Alpes, including one in a retirement home and nine in the hospital. The incidence rate is 14.1 (14.1 cases per 100,000 inhabitants).

In the Alpes de Haute-Provence

According to figures from the ARS, four people are hospitalized. No patient is placed in intensive care. Since the start of the epidemic, 13 people have died in the department and 133 have returned home. Regarding nursing homes, 24 residents have tested positive for Covid-19, 8 are hospitalized. The Regional Health Agency notes five deaths among residents of the Lower Alps, all in retirement homes. The incidence rate is 28.5 (28.5 cases per 100,000 inhabitants).

C. Cava Michard

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Model helps to interpret signs of life in space

More than 4000 planets outside of our solar system have now been discovered. But does life also exist on these heavenly bodies? To answer this question, astronomers analyze the light emitted from the atmosphere of an exoplanet. If you find methane or oxygen one day, for example, this indicates the existence of life.

The model developed by the scientists at EPFL and the University of Rome is based on how many such signs of life – so-called biosignatures – are discovered: one, several or none at all. The results were published in the specialist journal PNAS.

Among other things, the estimated number of sun-like stars in the Milky Way are included in the model. The researchers also took into account how many rocky planets could orbit their stars in a habitable zone.

According to the EPFL announcement on Tuesday, the probability that over 100,000 habitable planets exist in our galaxy is more than 95 percent – if a single biosignature is discovered in the future. The researchers also report that life could exist even if no biosignatures are detected. These would be life forms other than those on earth.

(sda)

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“I’m going through a mild form of depression”: Michelle Obama affected by pandemic and racism

In the last episode of her podcast, the former First Lady of the United States has not hidden his emotions and says he has been affected by the coronavirus pandemic and the race struggles that are shaking his country.

The morale of the formerFirst Lady of the United States is not always in good shape. In the new episode of his podcast, Michelle Obama claimed to suffer from a “slight depression”, due to the confinement linked to the Covid-19 pandemic but also the racial struggles in his country, as well as the “hypocrisy” of the Trump administration.

“I wake up in the middle of the night because something is worrying me, or because I feel a weight, says the wife of the former president Barack Obama. I try to play sports, but there were times in my forties when I just didn’t feel good. ”

“A form of mild depression”

Michelle Obama assures that she also goes through “these emotional ups and downs that everyone feels”. Moments “during which we do not recognize each other”. “This is not a time to flourish, spiritually,” she continues. “I know I’m going through some kind of mild depression. Not just because of my forties, but also because of race struggles. And to see this administration, to see its hypocrisy, day after day, is demoralizing. “

Read also “ “You are cute, you know it”: Barack and Michelle Obama in a private podcast

In video, “Becoming”, excerpt from the documentary on Michelle Obama

The former First Lady then explained in The Michelle Obama Podcast, broadcast on Spotify, that it was “exhausting” to “wake up and see yet another new story about a black man or black person being dehumanized, injured, killed or falsely accused ( e) something ”. “And that poses a burden that I haven’t felt for a while in my life,” she blurted out. Michelle Obama refers to the tensions that have rocked the country in recent months. The United States was the scene of anti-racist protests sparked by the death in late May of George Floyd, an African-American forty-something who died following a violent police arrest. “We are at a unique moment in our history. We are going through something that no one in our lifetime has experienced. ” One thing is certain: Michelle Obama has not finished breaking the codes.

The editorial team advises you

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What do we know about the violent clashes that took place in Dijon ?

Question asked by Dzamil the 15/06/2020

Hello,

Your question is about the events that took place this weekend on 13 and 14 June in Dijon and around, in the Burgundy region. On social networks, flocking of multiple videos showing violent clashes.

Several pictures show some of the bands who wander in the city centre and take it to a shisha bar, the Black Pearl, located in the boulevard de la Trémouille, not far from the Republic square.

On some videos, posted online Sunday, including several dozen men are visible. They compete, sometimes with bare hands, sometimes by means of iron bars.

Other, filmed by witnesses from different angles, show a car seeming to rush right on a mob before the aircraft struck an earth-full and from in barrels, at very high speed.

On videos more graphics (that CheckNews has chosen not to relay), we can see the car stopped, just after the accident. The driver, dead, is, in part, défenestré. His hands are in blood.

On Twitter, in the comments, reference is made repeatedly to clashes “between the Chechens and dealers“.

All these scenes fit effectively in a global context of clashes that went on for several days. The prefecture of Côte-d’or, contacted by CheckNewsconfirms that these events are likely related to settlements of accounts : “The weekend that has just ended has been marked by violence committed in the agglomeration of dijon, france, it seems, in the context of a settlement of accounts between members of the chechen community in France and the residents of the district of Grésilles and other districts of the metropolis-dijon”, she says.

Investigation

The prefect “condemns these behaviors […] with the greatest firmness” and indicates that a judicial investigation is now open.

Eric Mathais, the chief prosecutor of Dijon, has not responded to the demands of CheckNews. But as of this weekend, in the local press, the vice-prosecutor was state ten wounded, “some seriously”, during the descent to the shisha bar on the Friday night. The prosecution also confirms that injured by bullets, Saturday night, always in Dijon.

This Monday, he responded to our confreres from France Blue. About the driver involved in an accident, it confirms that the latter is currently in hospital in a serious condition. The scene took place in the district of Grésilles, in the north-east of Dijon on Sunday night. The prosecutor explains : “We were live at the command center of the police, we saw on the cameras these 140 people from the chechen community gathered on the market square to Grésilles. And there was a vehicle that came close, which, indeed, at a given moment sketched a movement to rush in the crowd, then there was this accident.”

In this interview, the attorney also confirms the opening of an investigation entrusted to the directorate for interregional judicial police and urban security, Dijon, france. But, he said, no arrest has yet taken place at the present time. The priority, according to him, is to secure the situation in order to avoid the worst.

About facts, it evokes a “drift community on racism. These are apparently members of the chechen community who have called on social networks from Friday to avenge the violence committed on a young by people from the community in the maghreb. Three nights in a row, it was therefore up to 140 people who come to Dijon in this context”.

Violence in Nice

According to France 3 Provence-Alpes-Côte d’azur, this violence is are now exported up to Nice, where shots were recorded in the district of Chestnuts, in the night of Sunday to Monday. Again, a video shows the shot. Nice Morning indicates that three men of chechen origin had been injured and that six people are currently in police custody.

For the time being, to Dijon, the authorities are trying to avoid escalation. The prefecture said that on Monday evening still, “a squadron of gendarmes mobiles will be deployed on the ground.” The day before, a half-section of SRC and reinforcements of the TRAY were on the ground.


Listen to the weekly podcast of the behind the scenes of CheckNews. This week :

Listen to the new episode of the podcast Checknews. If nothing appears, click on this link.

A Brussels of 19 years, accusing the forces of the order of the have “typed” and “insulting” on the sidelines of an event in tribute to George Floyd in the belgian capital on June 7, 2020. While the video, where the young man appears to be the wounded face goes viral, journalists Anais Condomines and Vincent Coquaz are trying to trace the source of the story.

Anais Condomines

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Podcast Pope Francis on the site of the Cross

A big thank you to Nicolas Senèze and other artisans of The Cross for these seven podcasts available on the website of the journal and made the occasion of the seventh anniversary of the pontificate of pope Francis. They are quite remarkable for their quality, their density, their clarity !

Each morning after our breakfast, we two, happy retirees, can take the time to listen to (and listen to) just one or two. And as we’ve seen with great happiness the movie The Two Popes on Netflix, we can continue to follow with great hope for the slow and laborious transformation of the Church.

Madeleine and Gérard

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Is it true that nicotine users contract Covid-19 less?

Hello,

Numerous case studies demonstrate this unequivocal : smokers who get Covid-19 have a risk greatly increased to develop severe forms of the disease. In this work, we find that the proportion of smokers is two to four times higher in severely ill patients than in those with a moderate form of the disease.

On the other hand, several publications relayed since the beginning of April report a counterintuitive phenomenon: in several countries, the proportion of smokers infected with SARS-CoV-2 would be lower than the proportion of smokers at regional or national level. The Minister of Health, Olivier Véran, recently mentioned this data.

In France, works being published conducted on a limited number of patients at the Pitié-Salpétrière, as well as a study in a school environment in Crépy-en-Valois (prepublished this April 23), also reported this statistical trend.

Many potential limits

Note now that the link between smoking status and propensity to be infected does not appear in all research. So in a recent study published in the Jama, involving 5,700 New York patients hospitalized for Covid-19, the proportion of smokers was analogous to that observed in the regional population.

The first studies were met with skepticism, not without reason. Indeed, many of these works have sometimes significant biases.

First limitation present in all studies (with the exception of French studies): the age parameter of hospitalized patients. Indeed, a significant proportion of patients with severe forms of Covid-19 are over the age of 65. The prevalence of smokers decreases very strongly with age (for example, in France, 65-75 year olds smoke 2.5 times less than the general population).

In the study conducted at Pitié-Salpêtrière, taking into account the age and sex of the patients, smokers nevertheless appeared to be four times less likely than non-smokers to be Covid +. A rate observed both in hospitalized patients and in patients treated on an outpatient basis. However, in order to draw more solid conclusions, these results should have been put into perspective with the smoking profile of patients who usually attend this hospital, at the same periods in previous years.

Another parameter that seems to be excluded from most analyzes: the socio-economic profile of the groups studied, which can strongly influence the expected proportion of smokers. A limitation mentioned by the authors of the French study, who established their calculations “Assuming that the population studied who lives in a limited area around a Parisian hospital has the same smoking habits as the French population in general”, and who note that “Healthcare workers were overrepresented in the outpatient group due to routine workplace testing when they became symptomatic”. The study conducted at Crépy-en-Valois seems to take this parameter into account. And its results are consistent with the Pitié Salpêtrière study.

Third important pitfall: the quality of the information collected is not always there … far from it. In some studies used by epidemiologists to conduct their analyzes, the smoking status of the sickest Covid + patients was simply not informed. Commentators have also noted that one of these studies considered individuals to be “non-smokers” less than 30 packages per year – preventing any comparison with national statistics which relate to all cigarette consumers.

For its part, the study conducted at Pitié-Salpêtrière seems to consider as “former smoker” any person who had quit smoking at the time of his hospitalization … without mentioning the hypothesis that patients may have stopped smoking because of the first Covid-19 symptoms! A point which would considerably influence the results. Requested by CheckNews, Zahir Amoura, author of this work, has not yet commented on this point.

Is the phenomenon biologically plausible?

The interpretation of these statistics, as well as the extent of the associated phenomenon, are still questionable.

Researchers, however, have begun to explore the hypothesis of a direct causal link between smoking status and primary SARS-CoV-2 infection. The question arises indeed: from a physiological point of view, is it plausible that lungs exposed to tobacco are less permeable to this coronavirus? Could nicotine be involved in the phenomenon?

A possible link with the ACE2 receiver?

SARS-CoV-2 infects cells by binding to the ACE2 receptor, abundant on the surface, in particular, the cells of the mucous membranes and the alveolar pulmonary tissue. The expression of the gene corresponding to ACE2 is not identical in smokers and in non-smokers. Based on animal models, smokers have long been considered to express less ACE2 – which suggests a simple explanation for the phenomenon: less ACE2 induces a lower propensity for infection.

But recent data, which seem to be corroborated by new researchsuggest that in humans, smoking is associated with a higher expression of ACE2. A higher propensity for coronavirus infection would therefore be expected. The epidemiological observations mentioned above, suggesting a protective effect of tobacco, would therefore raise a paradox.

Several explanatory hypotheses have been formulated. Some authors have advanced that in all patients, infection with SARS-CoV-2 would decrease the availability of ACE2 receptors in the lungs. The biological processes that usually mobilize these receptors would be hindered, leading to various symptoms of the disease. People with more ACE2, even if they were infected, would develop fewer symptoms. However, this interpretation is challenged by the Crépy-en-Valois study, where the diagnosis of infection was made on a blood test, and not on a simple clinical assessment of symptoms.

According to other works, the nAChR nicotinic receptor could modulate the activity of ACE2. Could stimulating nAChR make infection through ACE2 more difficult? This fact is not yet proven. “The possibility of a reciprocal modulation between ACE2 and the nicotinic receptor is an interesting scientific question for which we have no answer”, insists Professor Jean-Pierre Changeux, co-author of a scientific article inviting this hypothesis to be explored.

La Pitié-Salpêtrière has announced the launch of several clinical trials in this direction. The first, conducted on caregivers, aims to compare the infection rate between a group carrying nicotine patches and a group carrying placebos patches. More trials need to be done on Covid + patients in hospital to assess whether nicotine affects the course of the disease – especially in smokers who are forced to quit as a result of hospitalization.

Nicotine and vaping: preliminary data not very encouraging

The return of associations of electronic cigarette users does not seem to go in this direction, however. According to the analysis of a questionnaire sent in early April to several thousand members of the AIDUCE and SOVAPE associations, the rate of patients suspected of being Covid + was similar whether or not there was nicotine consumption – around 2.5 %. “Although it concerns nearly 10,000 people, this citizen survey is inconclusive on a major protective effect of nicotine, note the associations in a press release. The first data show no major positive or negative effect of vaping when faced with the risk of contracting Covid-19 for vapers and their entourage. ”

Tobaccoologist Bertrand Dautzenberg, who had encouraged these associations to explore this hypothesis, notes on Twitter that the data was not collected under conditions “Respecting all the obligations of scientific studies”. He nevertheless considers that they are not showing strong signs of a beneficial effect of nicotine in reducing Covid-19 levels. ” He invites an analysis of the Health Database to further explore this hypothesis.

No reason to start smoking

The tobacco specialist recalls “That tobacco certainly brings a negative effect greater than that of a small benefit which is not confirmed at all”. “This leads to encouraging all doctors to advise and support smoking cessation for all smokers.” The authors of the Crépy-en-Valois study abound in this sense, recalling that tobacco is responsible for 75,000 deaths per year in France. “Smoking cannot therefore be offered as a way of protecting oneself against the new coronavirus”, they insist.

Unsurprisingly, this finding is similar to that of the authors of a review on the complications of Covid-19 related to smoking. “Risk factors for severe forms of Covid-19 (pulmonary and cardiovascular disorders, diabetes, etc.) are more common in smokers. Smokers with comorbidities should quit smoking by all means. ” They also observe that confinement can lead to social isolation and psychological distress that increase the need for smoking. [En outre], smoking is more prevalent among the economically less advantaged groups, and they are potentially more at risk for Covid-19. ”

For its part, the association Alliance contre le tabac urged the greatest caution with regard to speculative information in circulation. In the absence of more evidence, nicotine users, “Should not expect to be more protected than the population from the current epidemic”, she recalls. In addition, she advises non-smokers to use nicotine substitutes. A warning also formulated by the promoters of the Pitié-Salpétrière study or by the Minister of Health.

In summary

Although well publicized, epidemiological observations associating smoking and the risk of developing the symptoms of Covid-19 are difficult to interpret at this time. Under the hypothesis of a real cause and effect link, the biological mechanisms mentioned in the press are still hypothetical. None have yet been formally tested.

Listen to the weekly behind the scenes podcast of CheckNews. This week: Covid-19: what are the real figures for deaths in intensive care?

Jérôme Salomon, the Director General of Health, mentioned a mortality of 10% in intensive care of patients hospitalized for Covid-19. In this episode, Luc Peillon explains why this figure is largely underestimated.


Florian Gouthière

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Drosten on coronavirus: vaccination study gives hope

Updated April 24, 2020, 5:42 p.m.

A vaccination study from China comes to the conclusion that a dead vaccine in animal models has proven to be effective protection against the coronavirus. Such a vaccine could be relatively easily produced in “rough quantities” worldwide, as virologist Christian Drosten explains in the latest edition of the NDR podcast “Coronavirus Update”. Even if dead vaccines are risky, the virologist speaks of a worthwhile consideration.

More current information about the corona virus can be found here

Lockdowns and loosening, tracing apps, distance and hygiene rules – all of these are just tools that can help us the corona crisis to get through as well as possible. An effective medication could also help to relax the current situation significantly.

The global crisis can only really be ended by one vaccine. Only when this is available will we all be able to return to our usual life.

Hopes are high that scientists will find a vaccine as soon as possible. So far, it is assumed that this could be available in about a year.

A new study now gives hope Chinaby virologist Christian Drosten was discussed on Friday in the current issue of the NDR podcast “Coronavirus Update”. Eight monkeys were vaccinated in Beijing and then infected with the SARS-CoV-2 coronavirus. A first manuscript for the experiments is now available.

Vaccines are the simplest vaccines

“That got a lot of attention,” said Drosten: “It’s about a dead vaccine. It’s the easiest thing to do when you do a vaccine. You grow the virus in cell culture and then kill it, in this case a chemical. You add an adjuvant and make it a vaccine preparation that has an uncertain effect. “

In Europe and the USA, the approach with a not particularly modern dead vaccine was initially not considered, since the use is considered to be risky. For example, vaccination can also lead to an increase in the disease instead of offering protection, explained Drosten. Especially when used against Corona viruses.

On the other hand, such a vaccine could be available much faster than many other modern vaccine concepts. “And if it works, then you know from experience with other dead vaccines that you actually drive well with it. You could at least think of something like this as the first vaccine option in the early phase,” said Drosten.

Dead vaccine could be produced quickly

Especially since such a dead vaccine could be produced in “rough quantities, in many countries of the world at the same time,” as Drosten explained. Less developed countries are also able to do this, and even veterinary vaccine production lines could help manufacture the vaccine that is needed millions of times to vaccinate the world population.

Time could be saved during production, which is why a dead vaccine would be a faster option. And an effective one, at least in the animal model. Four rhesus monkeys were in Beijing Vaccinated three times every week, four other monkeys served as a control group. Some monkeys received a smaller dose of the active ingredient, others a larger dose, and finally all animals were exposed to a large amount of the novel pathogen.

According to the study, the monkeys produced antibodies very well after vaccination, and their lungs were also protected from the infection. “What has been seen has been clear protection even against this very high exposure dose of virus, so much more than a human patient would get in a natural infection, “explained Drosten.

“A worthwhile consideration”

The dead vaccine was able to protect the monkeys effectively from COVID-19, it would also be relatively easy to manufacture and therefore probably more quickly available. Nevertheless, it would of course still be a long way until the vaccine was actually ready for use.

Drosten did not comment on a schedule. The results of the Chinese studies should be discussed first and foremost in science and society, said the director of the Institute of Virology at the Berlin Charité. “It’s worth considering whether you don’t want to go that route,” he said.

Because something else about the manuscript from Beijing gives hope. Studies on the effectiveness of the vaccine in humans have already started there.

Professor Dr. Christian Drosten is head of the Institute of Virology at the Berlin Charité and one of the leading virus researchers in Germany. The 48-year-old is considered a co-discoverer of the SARS virus. Immediately after the SARS pandemic in 2003, he developed a test for the newly discovered virus, for which he was awarded the Federal Cross of Merit in 2005. In the current corona crisis, the native of Emsländer is in demand as a conversation partner, he provides information on the current situation on a daily basis.

Prof. Lars Schaade warns of a “landslide of further easing” in the corona pandemic. The Vice President of the Robert Koch Institute thus appeals to the discipline of the citizens and the patience of the state governments: “We must not be careless now.”

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