Cardiomyopathy

New Molecular Mechanism Linked to Inherited Heart Disease

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Researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have identified a new molecular mechanism driving hypertrophic cardiomyopathy, the most common inherited heart disease. A study published in Nature Cardiovascular Research confirms that the targeted therapy mavacamten remains effective across various genetic mutations, potentially expanding treatment options for the estimated 95,230 patients living with the … Read more

How Fat Tissue Fuels Triple-Negative Breast Cancer Spread

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Researchers at the Hackensack Meridian Center for Discovery and Innovation (CDI) and Georgetown University’s Lombardi Comprehensive Cancer Center have identified “adipomes”—extracellular vesicles released by fat tissue—as active drivers in the spread of triple-negative breast cancer (TNBC). By isolating these vesicles, the team discovered they deliver a “lipid code” that reprograms cancer cells to form invadopodia, … Read more

Protein Repair Defects: A Hidden Cause of Heart Failure

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Researchers at the Medical University of South Carolina (MUSC) have identified a fundamental defect in the protein repair systems of patients with idiopathic dilated cardiomyopathy (IDCM). According to a 2026 study published in the Journal of Molecular and Cellular Cardiology, this breakdown in cellular maintenance leads to the accumulation of misfolded protein plaques, mirroring processes … Read more

Diabetes Drug Significantly Reduces Heart Failure Risk in Genetic Carriers

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New research published in Nature Medicine reveals that the medication dapagliflozin significantly reduces the risk of heart failure in patients who carry specific cardiomyopathy-associated genetic variants. Findings from the Mass General Brigham Heart and Vascular Institute and the Broad Institute of MIT and Harvard suggest that these genetic markers could help clinicians identify patients who … Read more

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