Researchers make significant progress in understanding protein aggregation in Parkinson’s disease

Scientists utilizing computational models have achieved a major breakthrough in comprehending how alpha-synuclein proteins aggregate, a process crucial to the development of Parkinson’s disease. This study represents the first detailed molecular mapping of these proteins, revealing how environmental factors such as molecule crowding and ionic changes enhance their aggregation.

The research team simulated the collective behavior of alpha-synuclein under various conditions and found that both crowder molecules and salt affect aggregation through distinct mechanisms. This advancement not only deepens our understanding of neurodegenerative diseases but also opens up new avenues for exploring potential prevention and treatment strategies for conditions like Parkinson’s and Alzheimer’s.

Key Findings:

1. Computational models demonstrate that crowder molecules and ionic changes stimulate alpha-synuclein protein aggregation, a key factor in Parkinson’s disease.
2. The study reveals that environmental conditions significantly impact protein behavior, with simulations uncovering different aggregation mechanisms triggered by crowders and salt.
3. This research emphasizes the importance of molecular dynamics in comprehending neurodegenerative diseases, providing opportunities to explore therapeutic interventions further.

IDPs (intrinsically disordered proteins) play critical roles within t

According to the 2020 statistics of the “World Health Organization”, the rate of deaths from heart disease per 100,000 people has been announced. Azerbaijan (388) ranks second in the list of 183 countries. Looking at women and men, the indicator per 100,000 people is as follows: in women – 325.04, in men – 465.72. The number of cardiovascular system diseases continues to increase not only in Azerbaijan, but all over the world.

On the issue Uzeyir Rahimov, head of the cardiology department of “Baku Medical Plaza”, doctor of philosophy in medicine, chairman of the Azerbaijan Cardiology Society Publika.azspoke to

He noted that there are serious problems in the indicated statistics:

“Sudden cardiac arrest is written as the cause of death on the death certificate of every person who dies in small countries like ours. The cause of death is neither considered nor investigated. If a patient dies from an oncological or infectious disease, it is diagnosed as a sudden cardiac ar

With more than 2.7 million cases reported since the beginning of 2024, the region most affected by the dengue is he Southern Coneintegrated by Brazil, ArgentinaParaguay and Uruguay, according to the Pan American Health Organization (PAHO).

It is an infection caused by a virus that is transmitted by the bites of female mosquitoes. Temples of the Egyptians infected. Only one in four people infected with the pathogen have symptomswhich can range from mild to serious.

In addition to the symptoms of the disease, it must be taken into account that the dengue can cause a sudden increase in hematocrit with rapid decrease in platelet count. These parameters can be known through a blood test.

Las platelets They are particles in the blood that help clotting. They are smaller than red and white blood cells.

The number of platelets in the blood can be affected by many diseases and their counting can be done to monitor or diagnose diseases, or to look for the cause of too much bleeding or clotting.

“Due to dengue infection, platelets can decrease. It is because the human body mistakenly produces antibodies against the virus, but generates a decrease in platelets,” he explained to Infobae Leda Guzziinfectious disease doctor and member of the Argentine Society of Infectology (SADI).

“Mystical and very beautiful,” is how anesthesiologist Edda Tschernko describes the moment when a heart begins to beat in a new body. 40 years ago, such a heart transplant was successfully carried out in Vienna for the first time – it has now become a medical success story with a survival rate of 75 percent after ten years, it was said on Wednesday at a press conference by the General Hospital and MedUni Vienna. “Vienna has thus established itself as one of the largest heart programs in Europe,” reports Daniel

(ANSA) – ASSISI (PERUGIA), 02 APR – The facade of the Upper Basilica of San Francesco in Assisi will also light up blue this evening on the occasion of World Autism Awareness Day. It will do so by joining the global awareness campaign “Light it up blue 2024” again this ye

This is what we will talk about today in this article; As many women may accumulate fat in the abdominal area, this makes them always search for the best ways to get rid of fat permanently, as natural methods are the best solution to fat problems. Removing belly fat without dieting. Cardamom is a well-known spice that gives a strong flavor to foods. It also contains many benefits for the body. Today in this article, cardamom is used with natural ingredients to increase fat. The ingredients are the following: 2 tablespoons of ground cardamom.

2 tablespoons of low-fat milk and 2 tablespoons of diet sugar. Preparing the cardamom recipe. Preparing the cardamom recipe for weight loss is as follows: First, bring a suitable bowl and put the milk in it, then stir from time to time. The next step is to do this when the milk is hot, add the ground cardamom and stir well for five minutes. After that, we add the sugar and stir well until it is well dissolved, then remove it from the heat and leave it to subside.

Then take it twice a week in the morning and evening before bed, and you will notice the difference within a short period. Benefits of cardamom for the body

Cardamom, or what is known as cardamom in many countries, contains very large nutrients, and the most prominent benefits that we obtain from it are as follows: It contains some antioxidants.

It acts as an anti-inflammatory that protects against many diseases.

It helps solve digestion problems such as stomach ulcers.

Treats bad breath. It is used as an antibacterial and is very effective. Benefits of cardamom: Adding spices to drinks and meals can improve digestion and increase metabolism. In addition to cardamom, adding spices such as fennel and cloves to drinks and sou