Groundbreaking CRISPR Gene-Editing Treatment Restores Vision in Patients with Inherited Blindness, Study Shows
For many people, the ability to see clearly is something that is often taken for granted. But imagine living your entire life with limited vision, watching the world through a small straw hole. This has been a reality for college student Olivia Cook, who was born with an inherited retinal disorder known as Leber congenital amaurosis (LCA).
LCA is a rare type of eye disorder that causes blindness, making it difficult for individuals to see people’s faces and details in dimly lit places. However, Cook’s life took a hopeful turn when she decided to participate in a clinical trial involving an experimental gene-editing treatment using CRISPR.
CRISPR-Cas9 gene editing has been making waves in the scientific community due to its potential to treat genetic disorders. In Cook’s case, this groundbreaking technology was used to correct the form of inherited blindness caused by LCA.
The results of the Phase 1/2 clinical trial showed promising outcomes for Cook and other participants. Among a total of 14 volunteers, including Cook, most experienced signif
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Israeli pride, Croatian rock anthem and Ukrainian feminism: Eurovision 2024 will open tonight in Malmö
Eurovision 2024 kicked off tonight (Tuesday) at 22:00 Israel time in Malmö, Sweden, with 15 songs from 15 countries hoping to be among the ten that will advance to the final on Saturday night. As last year, the audience’s vote will determine the results of the semi-finals, without the intervention of the professional judging teams, whose opinion will only be heard in the final.
For the first time, the organizers of the competition decided that the six automatic participants in the finals will also be placed among the songs in the semi-finals, and thus the viewers will get to know them fully like all the other songs.
These are the songs of the first semi-final, divided into completely subjective categories:
The countries that came to win
CroatianGod: A sweeping rock song about a young man who leaves his hometown, his family and the farm animals. An exciting story familiar to many Europeans, seasoned with humor and stage charisma. Since Baby Lasagna’s win in the Croatian preliminaries, he has been leading the betting tables almost continuously, and after his first returns he even opened a gap from the competitors. After the Italian win in 2021 with a kicking rock song, the Croatians dare to dream of a first Eurovision victory as an independent country. They will go to the final for sure.
Ukraine: Aliona Aliona, one of the most successful singers in Ukraine, joined Jerry Hale, which was her third participation in the local show. With lyrics in English and Ukrainian about female empowerment (“all divas were born human”), an impressive rap section and an infectious chorus, and of course with the sympathy of Europe and the desire to provoke Russia, the Ukrainian duo was marked as one of the top songs of the year. The short video clip released from the rehearsal made the song soar in the betting charts. If Ukraine gets a fourth victory, it will be especially impressive for a country that only started participating in 2003.
The countries that saw “cha cha cha” and wanted too
Ireland: Bambi Thag, semi-binary Swedish singer, responsible for a
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https://www.worldysnews.com/israeli-pride-croatian-rock-anthem-and-ukrainian-feminism-eurovision-2024-will-open-tonight-in-malmo/
what is this molecule at the origin of the disease?
#molecule #origin #disease
In France, at least 17 million people are affected by allergic diseases. But as surprising as it may seem, the mechanisms of inflammation at the origin of certain respiratory diseases – such as asthma or hay fever – still remain poorly understood.
A team of French researchers is opening a new door in understanding these pathologies. They have in fact identified one of the molecules responsible for triggering the allergic reaction
New treatments
“This molecule from the alarmin family, named
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Your period pain is not normal, these signs prove it
Our gynecologist is categorical: “It’s not normal to have pain during your period.”
The menstrual cycle is a physiological phenomenon which punctuates women’s lives and which is accompanied by numerous symptoms: fatigue, mood changes but also sometimes pain. Gold “It’s not normal to have pain during your period“ explains gynecologist Odile Bagot. In medical language, painful menstruation is called “dysmenorrhea“. Dysmenorrhea can be primary when it occurs in adolescence or secondary when it appears throughout the menstrual cycles. It can have several causes and be more or less disabling on a daily basis.
Ovarian pain
Pain may occur around theovulation i.e. around the 14th day for women who have 28 day cycles. We talk about “cyclical” pain. “If a woman presents with cyclical pain, the reflex will always be to analyze them in relation to the date of the period. This is the benchmark. The healthcare professional will then be able to relate them to menstruation or not” explains Dr. Bagot. Ovulation results in a small 2cm cyst that bursts. It can lead to “sensations” in women who feel a temporary discomfort. There is nothing to worry about. On the other hand, if ovulation is associated with significant pain during 2 to 3 days, you should talk to the doctor. “Sometimes we see ovaria
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«States responsible for damages». Ursula’s buck-passing on vials
Alexander the Great brought it from the Far East to the Mediterranean. Since then he has entered our kitchens. Its medicinal virtuesAlexander the Great brought it from the Far East to the Mediterranean. Since then he has entered our kitchens. Its medicinal virtues help against nausea, vomiting and poor digestion. But it is not a panacea that is good for everyone.
beautiful gum galls.” One might not recognize it, since the poet, as we have just seen, calls it gengiovo. But it is not poetic license: gengiovo was the name of ginger at that time and, in general, in ancient times. The history of the name of this spice over time and around the world is as fascinating as discovering its merits. The botanical name of ginger is Zingiber officinale: it is a herbaceous plant originally from the Far East but now very familiar to us too. It belongs to the Zingiberaceae family, genus Zingiber, species, precisely, Zingiber officinale. Officinal because ginger is a plant used not to feed, but to heal. The original name, singivera, belongs to the Middle Indian language, now extinct. At a certain point, the plant arrived in the Mediterranean with the soldiers of Alexander the Greatreturning from the Asian military campaigns, and with it came the original name that each territory remodeled in its own way. For example, in French it is gingembre, in English ginger, in Dutch gember, in Romanian ghimbir, in Spanish jengibre. In current Italian ginger, with dialectal variations always relevant to the original name, such as the Friulian zenzevar, the Sardinian zìnzalu, the Sicilian gènciru, the Venetian xènxaro (or denèver).
Moving from the name to the thing that the name denotes, we see that the ginger plant is composed of a beautiful plump and lumpy root on which, above the level of the earth in which the root is buried, stems with lanceolate leaves and small yellowish-greenish flowers stand out which then evolve into fruits. Each fruit is a capsule divided into three lodges, but ginger flowers are unknown: we only use the root. The root, also called rhizome, contains the active ingredients that we exploit for our health and which are also responsible for the strong, almost spicy flavor of our ginger: active ingredients such as gingerols, then derivatives of gingerols such as zingerone and shogaoli and the volatile elements of the essential oil i.e. sesquiterpenes, such as zingiberene and B-bisabolene, and other monoterpenes. The fresh root must be peeled and the remaining pulp cut into small pieces as is done with garlic cloves. Or cut into thin slices. Another form, in addition to these, in which you may find ginger, is the powder, which is made by drying and then pulverizing the root. In both cases, we use ginger as a flavoring or as a spice, it is clearly not the case to consume ginger roots in bites as if they were aspa
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«States responsible for damages». Ursula’s buck-passing on vials
The Impact of Temperature Fluctuations on Skin Diseases: Understanding and Treating Tinnitus
[미디어파인 전문칼럼] As the temperature difference between day and night increases, the immune system weakens and skin diseases such as rashes, atopy and psoriasis can worsen, so it is necessary to be in the company of others.
Tinnitus is a superficial skin infection caused by Malassezia, a type of fungus.
It occurs mainly on the upper part of the body, particularly on the chest, back, armpits and neck, where sebum secretion is high. Mold can be commonly observed in our daily lives. It is especially common during the hot and humid summer season and tinnitus also occurs frequently during these seasons and recurs repeatedly.
The most characteristic feature of tinea rash is the mottled spots like ringworm. Colors vary wide
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The Impact of Temperature Fluctuations on Skin Diseases: Understanding and Treating Tinnitus
A new genetic form of Alzheimer’s disease identified. « Medicine in the Library
A new genetic form of Alzheimer’s disease identified.
Posted by giorgiobertin on May 7, 2024
The results of this study conducted by researchers at Research Area on Neurological Diseases, Neuroscience, and Mental Health at the Sant Pau Research InstituteSpain, indicate that the APOE4 form of the APOE gene, already “investigated” for some time in the context of Alzheimer’s, is strongly correlated with the risk of onset of the disease.
In particular, people whose genome contains a double copy of this form of the gene – called APOE4 homozygotes – have a very high probability of developing the disease and of developing it earlier than those with other variants of the same gene. So much so that homozygosity for APOE4 could represent a new genetic form of the disease.
In this work, researchers evaluated clinical, pathological, and biomarker changes in APOE4 homozygotes to determine their risk of developing Alzheimer’s disease.
The findings suggest that virtually all APOE4 homozygotes exhibited Alzheimer’s pathology and had
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A new genetic form of Alzheimer’s disease identified. « Medicine in the Library
Fatebenefratelli to support family caregivers – Health and Wellbeing
(ANSA) – MILAN, 06 MAY – To recognize and support the role of family caregivers, which is particularly difficult when the patient is a person with cognitive impairment, the Istituto Centro San Giovanni di Dio- Fatebenefratelli, in collaboration with community points of Brescia and the Municipality of Montichiari, offers a month of events, awareness meetings, experiential workshops and training
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Fatebenefratelli to support family caregivers – Health and Wellbeing
Preventing Viral Hepatitis: Information and Tips from Doctors Association in Lebanon
The Health, Cultural and Media Committees and the Citizen Education Committee of the Doctors Association in Lebanon distributed a short health bulletin on Viral Hepatitis of the Millennium in all governments, especially in towns and cities.
The leaflet contained the following information:
Pathogen: Hepatitis A virus
Modes of transmission: through contaminated water, contaminated drinks, contaminated food, eating raw or undercooked meat and fish, or contaminated hands. The incubation period of the disease extends from 28 to 30 days after infection.
Symptoms of the disease: high temperature (fever), malaise, loss of appetite, diarrhea, nausea, abdominal discomfort, dark urine, jaundice (yellowing of the skin and eyes).
Diagnosis: Blood tests are used to detect signs o
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Preventing Viral Hepatitis: Information and Tips from Doctors Association in Lebanon
Diabetic retinopathy: a silent epidemic
Diabetic retinopathy, an ocular complication of diabetes, is positioned as a global public health concern.
It is estimated that approximately 93 million people in the world live with diabetic retinopathy, and this number is expected to increase to 160 million by 2040 if adequate preventive and treatment measures are not taken.
Who it affects and how it develops
Diabetic retinopathy is an eye condition that affects people who have diabetes, especially those with poor glycemic control over time. It is estimated that at least one third of people with diabetes will develop some degree of diabetic retinopathy during their lifetime.
It is crucial to highlight that diabetic retinopathy can be asymptomatic in its initial stages, which underlines the importance of performing regular ophthalmological examinations, at least every six months, to detect any early signs of the disease. As the condition progresses,
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