According to an analysis of data from the UK Biobank, in addition to losing the genetic lottery, at least 15 factors, such as alcoholism, social isolation and hearing loss, significantly increase the risk of developing early-onset dementia.
Around four million people under 65 worldwide suffer from dementia symptoms, such as short-term memory loss, learning difficulties and behavioral disorders. At the same time, doctors are increasingly diagnosing dementia praecox, which amounts to almost 370,000 new cases per year. Since dementia primarily affects the elderly, the early manifestation of the disease has been seen as a one-drop effect in a largely genetic sense. Dementia is much more common in people with certain genetic variants.
In their recent work, Dutch and British researchers set out to examine how important a person’s lifestyle and environment are in addition to genetic predisposition. The dataset, covering almost 375,000 people, made it possible to discover whether the link with dementia is real or due to coincidence, even in the case of factors with a modest effect. In total, the working group assessed the impact of 39 possible risks in this way.
Based on the results, 15 factors were strongly associated with dementia. A sharp drop in blood pressure accompanying rising from a lying position has been strongly associated with the early onset of dementia. People who reported it were four times more at risk of contracting the disease. People with depression were three times more likely to be diagnosed with dementia. Excessive alcohol consumption and stroke also carry more than double the risk.
However, other risk factors included poverty, heart disease, hearing loss, diabetes, hearing loss, social isolation, and vitamin D deficiency. In the analysis, longer education, moderate alcohol consumption, and greater Hand grip strength appeared to be associated with a lower risk of early dementia.
Therefore, the risk factors for both early dementia and dementia in older adults largely overlap. To avoid chronic stress, loneliness and depression, it is worth working even for the youngest. Likewise, improving your physique is helpful.
According to previous research, about four in ten cases of dementia are due to preventable risks, such as smoking, high blood pressure and hearing loss. If current trends continue, dementia will be three times more common by 2050 than it is now, according to the World Health Organization.
The study was published in JAMA Neurology.
2023-12-29 09:37:00
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