Unlocking the Mysteries of Gene Regulation and Epigenetics: The Power of New Technology
Epigenome Editing Platform Revolutionizes Gene Regulation Studies
An innovative epigenome editing platform has been developed by researchers, allowing for precise programming of epigenetic modifications throughout the genome. This cutting-edge technology utilizes CRISPR to target and alter chromatin, enabling detailed investigations into the impact of these modifications on gene expression.
Through the implementation of this system, researchers have uncovered novel functions of chromatin modifications, challenging existing beliefs about their influence on transcription. This breakthrough not only enhances our comprehension of gene regulation mechanisms but also creates opportunities for personalized medicine by enabling controlled gene activity modifications.
Key Insights:
- Advanced Platform: The newly devised system permits accurate application of epigenetic modifications to any genomic site, leveraging CRISPR technology for precise editing.
- Revelation of Novel Gene Regulation Pathways: Initial findings indicate that specific chromatin marks, such as H3K4me3, previously considered byproducts of transcription, can actively boost gene expression when introduced to specific DNA regions.
- Potential for Tailored Medicine: This technology sets the stage for potential therapeutic applications, where targeted epigenetic modifications could regulate gene activity tailored to individual patient requirements.
Source: EMBL
Understanding the intricate mechanisms of gene regulation at the molecular level poses a central challenge in contemporary biology. This intricate process primarily hinges on the interplay between transcription factors, DNA regulatory regions, and epigenetic modifications – chemical alterations that modify chromatin structure.
The collection of epigenetic modifications on a cell’s genome is known as the epigenome.
In a recent study published in Nature Genetics, researchers from the Hackett Group at EMBL Rome have introduced a modular epigenome editing platform – a system for programming epigenetic modifications at any genomic location.
The system allows researchers to investigate the influence of each chromatin modification on transcription, the process by which genes are transcribed into mRNA to facilitate protein synthesis.
Chromatin modifications are believed to play a role in
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Unlocking the Mysteries of Gene Regulation and Epigenetics: The Power of New Technology
20 Jobs Not Threatened by Artificial Intelligence
Artificial intelligence (AI) has identified the safest and most at-risk jobs, with experts predicting that artificial intelligence will replace 300 million full-time jobs in the coming years.
A study by investment bank Goldman Sachs found that artificial intelligence could take over a quarter of jobs in the US and Europe.
Like all technological advances, artificial intelligence will change the way we work, eliminating some jobs but creating others.
The report says that generative artificial intelligence like ChatGPT, which is capable of creating human-like content on the fly, is a ‘major advance’.
Earlier last year, telecoms giant BT announced it would cut 55,000 jobs by the end of the decade, replacing around 10,000 with artificial intelligence (AI) to cut costs. .
Prospect, one of the UK’s largest trade unions, found that a majority of workers believe the government should introduce rules on the use of generative AI (such as ChatGPT) to protect jobs, which But 58 percent of workers support regulati
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Apple apologizes for the controversial announcement of its new iPad and will not broadcast it on television | Technology
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7 Days to Die announces the end of its Early Access… and that the game will have to be purchased again on console
The Fun Pimps have announced the end of Early Access for 7 Days to Die… with controversy included.
The open-world zombie game was originally published in 2013. Now, after eleven years, it will end its early access phase and version 1.0 will be released. The surprise, however, is that they have said that users who bought Early Access on consoles (which was not exactly cheap, costing €34.99) will have to buy the game again if they want the fi
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This is how Thujen and his companions become strong again
The hedge in the garden is a privacy screen and a design element. Expert Wolfgang Praskac knows what care older thuja and yew hedges need.
They are among the most popular hedge plants the Austrian: the Thuja and the badger. They have the advantage of being green even in winter, guaranteeing good privacy and being easy to cut. However, KURIER reader Wolfgang Erhart’s plants are weakening: “My yews and thujas are starting to thin out in the lower area and die. How can I give them new strength?”
Turbo for the hedge
Garden expert Wolfgang Praskac advises: “Due to the somewhat weak and pale appearance of thuja and yew hedges, it can be concluded that the plants have been suffering from a nutrient deficiency for a long time. This results in the diluted appearance. Now it is important to do everything so that the plants feel comfortable again quickly. It is recommended to clean or cut anything that is dry or fallen from inside the hedge, to water regularly – abundantly and thoroughly, every 8-14 days depending on the weather – and to immediately apply fertilizer, preferably a special turbo for hedges. If hedges have been around for a long time (up to decades), the soil may leach or become tired. This makes it even more important to pay attention to adequat
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Lineage 2M: Magic Cannon Chosen as Care Rush Class with New Skills and Revamps
NCSoft’s MMORPG “Lineage 2M” has chosen Magic Cannon as its Care Rush class. Class Care Rush, which is part of the class revamp, basically consists of two new skills and the revamp of existing skills.
Magic Cannon is the second original class of “Lineage 2M” and appeared in 2022. It is a long-range magic class that uses its long range to fight battles. Furthermore, it displays specialized skills in buffs and debuffs, and this Care Rush class also focuses on highlighting the Magic Cannon’s strengths.
Magic Cannon has been given two new abilities, Smog Barrage (passive) and Smog Shot (active). The Hero Level Smog Shot deals damage to up to 3 people within a certain radius and, with a certain chance, gives a debuff that reduces th
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Lineage 2M: Magic Cannon Chosen as Care Rush Class with New Skills and Revamps
IT security: Linux, MacOS X and UNIX at risk – update for IT security warning for Golang Go (risk: medium)
A security warning issued for Golang Go has received an update from the BSI. You can read about which products are affected by the security gap here on news.de.
The Federal Office for Security in Information Technology (BSI) published an update on May 7th, 2024 to a security vulnerability for Golang Go that became known on February 29th, 2024. The security vulnerability affects the operating systems Linux, MacOS
The latest manufacturer recommendations regarding updates, workarounds and security patches for this vulnerability can be found here: Oracle Linux Security Advisory ELSA-2024-2562 (As of May 8, 2024). Other useful links are listed later in this article.
Safety warning for Golang Go – Risk: medium
Risk level: 3 (medium)
CVSS Base Score: 7,3
CVSS Temporal Score: 6,7
Remoteangriff: Ja
The Common Vulnerability Scoring System (CVSS) is used to assess the vulnerability of computer systems. The CVSS standard makes it possible to compare potential or actual security vulnerabilities based on various metrics in order to better prioritize countermeasures. The attributes “none”, “low”, “medium”, “high” and “critical” are used to determine the severity levels of a vulnerability. The Base Score evaluates the requirements for an attack (including authentication, complexity, privileges, user interaction) and its consequences. The temporal score also takes changes over time in the danger situation into account. According to the CVSS, the threat of the vulnerability discussed here is classified as “medium” with a base score of 7.3.
Golang Go Bug: Multiple vulnerabilities allow unspecified attack
Go is an open source programming language.
An attacker could exploit multiple vulnerabilities in Golang Go to conduct an unspecified attack.
The vulnerability is identified with the individual CVE (Common Vulnerabilities and Exposures) serial numbers. CVE-2023-45289, CVE-2023-45290, CVE-2024-24783 und CVE-2024-24786 traded.
Systems affected by the security gap at a glance
Operating systems
Linux, MacOS X, UNIX, Windows
Products
Red Hat Enterprise Linux (cpe:/o:redhat:enterprise_linux)
Fedora Linux (cpe:/o:fedoraproject:fedora)
NetApp StorageGRID (cpe:/a:netapp:storagegrid)
Ubuntu Linux (cpe:/o:canonical:ubuntu_linux)
SUSE Linux (cpe:/o:suse:suse_linux)
Oracle Linux (cpe:/o:oracle:linux)
IBM MQ (cpe:/a:ibm:mq)
Red Hat Enterprise Linux Advanced Cluster Management for Kubernetes 2 (cpe:/o:redhat:enterprise_linux)
Grow To Grow To Red Hat OpenShift Container Platform Red Hat OpenShift Container Platform
General measures for dealing with IT security gaps
Users of the affected systems should keep them up to date. When security gaps become known, manufacturers are required to fix them as quickly as possible by developing a patch or a workaround. If security patches are available, install them promptly. For information, consult the sources listed in the next section. These often contain further information about the latest version of the software i
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LG OLED 55-inch B4 Classic Series Smart Display: Unboxing and Review
With the advancement of audio-visual technology, people are becoming more and more demanding in their pursuit of colorful audio-visuals, so they are more willing to invest in upgrading audio-visual entertainment-related products. Today, OLED panels have become synonymous with top-notch visual effects. But among the dazzling array of products on the market, interspersed with various marketing techniques, which smart TV is your ideal choice? As the saying goes, “Seeing is worth hearing a hundred times.” This time, we have personally tested this hot new product “LG OLED 55-inch B4 Classic Series Smart Display” on the Tutttt fundraising platform to see what its charms are.
LG OLED 55-inch B4 classic series smart display unboxing and actual testing: top-notch audio and video effects create a personal theater
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When choosing a smart TV, in addition to size, it is a large appliance that cannot be ignored at home. It is best to have a beautiful appearance and quality. If you have a sufficient budget, you will also want a panel with more exquisite color rendering. The sound effects with better immersiveness and other features, including the more intuitive and user-friendly operating interface, are all big plus points. If you are planning to change your TV recently, the LG OLED 55-inch B4 Classic Series smart display introduced this time is definitely worth putting on your pocket list.
LG OLED 55-inch B4 Classic Series Smart Display Buy Here
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As the largest electrical product in the living room, the first impression is very important, and whether the appearance is beautiful or not is the key to a lifetime decision. The size of the LG OLED 55-inch B4 is suitable for most consumers’ home spaces. The neat, slim and high-quality body does not look obtrusive whether it is wall-mounted or placed using the included simple tripod, even if it is necessary to add a connection port on the back. When installing new equipment, it can be easily moved even if you operate it alone.
The rear connection port provides 4 HDMI 2.1, one of which also supports eARC and ARC, and 2 USB Type A that can directly read files and charge devices. There is al
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LG OLED 55-inch B4 Classic Series Smart Display: Unboxing and Review
Apple Apologizes for Controversial iPad Ad After Backlash
Apple has apologized for an ad for the new iPad after an online uproar over the message.
The video shows a hydraulic press crushing a collection of creative objects – such as musical instruments and books – before an iPad appears on the screen. The message “The most powerful iPad ever is the thinnest” means that Apple can capture all of human culture in one electronic device.
A message that disturbed, for example, the British actor Hugh Grant, who wrote on Twitter: “The destruction of hum
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The device that could replace smartphones in the future
Nowadays most people cannot imagine life without smartphones but now a unique device is ready to take its place.
Every day the invention of science is increasing in which new things are introduced, one such unique device has been introduced at the Consumer Electronics Show in Las Vegas.
The device, called the Rabbit R1, fits in the palm of your hand and is equipped with artificial intelligence (AI) technology. With this device you can get answers to your questions, launch various apps or even call for a taxi.
But this is not a smartphone, but according to the company, it is a personal digital assistant that works on AI technology. The device was introduced
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