Although a good mix of candidates participated De Bachelorette, Gaby Blaaser appears to have passed on a number of requirements to the production. And they didn’t fully adhere to that …
Brown or blonde, muscular or not, and so on … In appearance, it seemed that the production had not received strict requirements for the candidates. Yet there was one thing that Gaby thought was very important, namely: the age limit. However, production didn’t seem to care much about it. According to Andre Montijn, in the no time could leave, he wouldn’t fit into Gaby’s ‘perfect picture’ in advance.
Casting
“She asked how old I was and was surprised I said 41. Apparently she had ordered the production team to cast men up to age 37. I happened to drop out that same night,” he tells the website Near. Then it soon became apparent that not only did he not match Gaby in terms of age, but that there was also not really one sparkle between the two. “We just don’t have the common ground that I’m really looking for.”
Cloving hospital on the basis of the Medical Scientific and Educational Center (ISSC) Moscow State University named after M.V.Lomonosov took the first patients on April 21 and completed his work on June 13. It turned out that it was possible to achieve the best treatment results for COVID-19 in Moscow. Over the entire period, 4 patients died, and among severe patients who got mechanical ventilation, the mortality rate was less than 14% (for comparison, the average for the city and the world was up to 70 – 80%). Eighteen doctors out of 220 employees of the hospital were infected with coronavirus, there were no deaths among the medical staff.
What approaches were used at the University Hospital of Moscow State University to achieve such results? We continue the conversation with the head. Department of Therapy, Faculty of Fundamental Medicine, Moscow State University, Head of the Department of Age-Associated Diseases, Medical Scientific and Educational Center, Doctor of Medical Sciences, Cardiologist Yana Orlova.
MEDICINE FOR COUGH FOR 80 RUBLES
– Most of those who are ill or are afraid to get sick are worried about fibrotic changes in their lungs. They say that you have developed special therapy that can reduce the risk of developing fibrosis. Is it possible?!
– Yes, we launched an appropriate clinical study. There are no final results yet, but we have developed clinical practice.
“What did you do to save the lungs?”
– We used a combination of bromhexine and spironolactone (both are long-known very cheap drugs. – Ed.). Bromhexine is an expectorant that has been prescribed to patients with pneumonia and cough for many years. At the same time, experimental data showed that this drug can block a specific enzyme and impede the penetration of coronavirus into cells. True, it was on this effect that we counted to a lesser extent in inpatients, since such an effect is important mainly in the early stages of the disease. But the expectorant effect of bromhexine really helps patients with COVID. I heard that our colleagues in Peter launched a study of bromhexine for prophylactic purposes. We will wait for the results.
Coronavirus infected 18 doctors from 220 employees of the hospital, there were no deaths among the medical staffPhoto: Ivan MAKEEV
FIBROSIS OBSTACLE
– The second drug – spironolactone – is traditionally widely used in cardiology for the treatment of heart failure, severe hypertension. It has a small diuretic, magnesium and potassium-preserving effect, continues Yana. Orlova. – It has several mechanisms through which it can be useful in coronavirus infection.
Firstly, a mechanism that prevents the development of fibrosis in general in the body. There are works that, in particular, show that spironolactone reduces fibrosis in the heart. At the same time, it is known that the tendency to fibrosis is not local, but systemic – where there is more inflammation, there will certainly be fibrosis. And we see, of course, fibrotic changes in the “covide” in our patients. Therefore, we prescribed spironolactone as a drug for the prevention of this process.
Secondly, this drug blocks sex hormone receptors, in particular testosterone. Some published studies suggest that “high-testosterone” men suffer from “covid” more often and develop more severe fibrotic changes. Therefore, blocking these receptors for several weeks during COVID treatment may be useful in reducing the severity of complications. We are not talking about a longer intake, since male patients are unlikely to agree with a decrease in testosterone levels in the long term.
And perhaps the most important point. In almost all of our patients, we observed hypokalemia (a decrease in potassium levels. – Ed.). With coronavirus infection, potassium is intensely excreted from the body, and scientific articles even suggest that hypokalemia serves as the trigger for a cytokine storm. So spironolactone has a real chance to reduce the risk of this dangerous complication. But the main thing, in my opinion, is that lowering the level of potassium in the body is extremely harmful to the heart and triggers life-threatening rhythm disturbances, increasing the risk of sudden death. We, like all others, replenished potassium with droppers, but it was more effective to retain it in the body with the help of spironolactone.
Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patientsPhoto: Ivan MAKEEV
WHEN PRESCRIBED PATIENTS
– Yana Arturovna, how many patients did you have on average?
– About 10 – 14 days. But someone and 50 days.
– Have you noticed signs by which it can be assumed that the disease in the person brought is likely to go the hard way?
– Such studies were carried out in the world, our clinical practice confirmed them. Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patients. Men with a classic male type of baldness, a lot of facial hair, we can say brutal men get sick harder.
– Under what conditions did you discharge patients?
– We acted as close as possible to the recommendations Ministry of Health: so that the temperature for three days was not higher than 37.5 degrees; so that C-reactive protein (an indicator of inflammation) is lower than 10 mg / l, and saturation, that is, the level of oxygen in the blood, is higher than 96%.
“HEAD OF EPIDEMIOLOGY DEPARTMENT OF ITSELF WORKED AT SANPROPUSNIK”
– How often do you get sick doctors and nurses?
– In the first month no one got sick at all. We have a very powerful epidemiological service. The head of the sanitary-epidemiological department, a senior researcher, correctly organized the whole process, and for the first two weeks she personally worked in the sanitary inspection room at the exit from the “red zone” and helped doctors and nurses who were exhausted after the shift safely remove protective clothing.
Then both people’s fatigue and viral load accumulated. By the middle of the second month, sick people began to appear. There were no seriously ill patients. We treated part of the staff in our observation, part of it was treated at home. In total, 18 people were infected from the medical staff (less than 10%).
– Doctors take something for prevention? Vitamins C, D, Zinc?
– I saw the recommendations of American nutritionists, they speak out positively about taking zinc, melatonin and vitamin C. There were somewhat conflicting data on vitamin D. But we did not give any such recommendations to our employees. We have all the prevention was associated with minimizing contacts and other measures of epidemiological safety.
Physicians are the heroes of our time.“If you think that you are special and that a pandemic will not affect you, you are deeply mistaken,” listen to what the doctors who are fighting with coronavirus say
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According to the survey, the behavior of those who have the sick among relatives and friends, different from those who do not believe in the epidemic and has no ill among the entourage. Respondents who have familiar cases, carefully observe measures of prevention and believe that it is too early to get out of isolation.
Faced with coronavirus illness friends are sure (43,4%), which restrictions during his isolation had to be more among the skeptics, this statement was supported by only 15%. Wear a protective mask outside the house of 70.1% from the first group, and only one-third (33.1%) from the second.
Attitude to the regime of isolation is changing as more and more people in their environment are confronted with cases of infection, said one of the study’s authors, Deputy head of the Directorate for expert analytical work, HSE Ruslan Artamonov. “There is a reassessment of risks and priorities, the safety of life and health comes to the fore. These people already understand the need for isolation, for what purpose it was introduced, and often seeing how often these measures are not met, even I agree that measures of self-isolation had to be more,” — said Artamonov.
The second wave, and the reluctance to be vaccinated
In the event of a second wave of the coronavirus more than half of respondents (54.4 per cent) will comply with the regime of self-isolation in the same way as the first time, and 4.5% of Russians are going to do it even stricter. Don’t be in such a situation, to follow a policy of isolation on their own is 14.2%, with another 8.4% are going to comply with only those rules, violation of which will fine. Tenth (9.8 per cent) of Russians will not be able to observe a mode in the second wave for a variety of reasons, primarily because of the need to go to work. According to the study half of the respondents (51,3%) for all time of existence of the regime of self-isolation continued to go to work.
To the question about whether the Respondent to be vaccinated against coronavirus in the case of in the near future the Russian vaccine, only 15.8% said that they would do such a vaccine immediately. Wait for foreign vaccine intend to 4.4% of respondents, and 10.6% and will make a decision about vaccination next year. A third of respondents (37,7%) is not going to be vaccinated against coronavirus never before.
The data about the Russians, who do not intend to be vaccinated against coronavirus, the HSE coincide with the data of the opinion poll, which was conducted in may. Thus, according to the poll, 35% of Russians would not get vaccinated against the coronavirus.
According to Artamonov, the vast majority of those who will not vaccinate, are Russians who do not believe in the epidemic, as well as principled opponents of any vaccinations. In addition, the solution-thirds of Russians to refuse to vaccinate against coronavirus has a relatively mild form of the flow with a smaller number of severe and fatal outcomes than in Europe and the United States.
“Russia decided to mass vaccinate only of the most deadly diseases — tuberculosis, measles, etc., and mostly in childhood. Children in the case of coronavirus not included in the risk group. Vaccination against milder disease with a small mortality are usually made by individual decision and not carry mass character”, — concluded the expert.
– Has long been known that overweight people have lowered immunity, says head of the Department of endocrinology of the medical faculty Russian national research medical University. N. And. Pirogov Tatiana Demidova. Research and practice show that in these patients increases the risk of atherosclerosis sharply increases the risk of heart attacks, strokes and heart failure. Increased risk of endocrinological, oncological diseases, joint diseases, psychological disorders.
Epidemic COVID has added another item to the list of high threats to people who are overweight. It turned out that when infected with coronavirus patients with obesity more often require hospitalization, fall into the ICU, on the ventilator (artificial lung ventilation). Alas, is growing and the risk of death.
– If the original messages from China on the most severe cases COVID it was mainly about the older people with severe chronic diseases, according to the latest data from Europe and USA the risk group includes people with obesity – says Tatiana Demidova.
FACTS AND FIGURES
In what diseases most often develop complications due to coronavirus
90% of patients admitted with severe COVID-19 US hospitals, were the following comorbidities:
– hypertension — 49.7%,and
– obesity or 48.3%,
– chronic lung disease — 34,6%,
– diabetes type 2 diabetes was 28.3%,
– cardiovascular disease — 27,8%.
Thus, obesity is second among the States in which CouId be severe.
CORONAVIRUS, INFLUENZA, AND HIV, “LIKE” ADIPOSE TISSUE
Visceral adipose tissue, that is, one that is in the abdomen, is, in fact, highly individual body, experts explain. This body affects the immune, endocrine system and metabolism in the body as a whole.
– People who are overweight fat cells are much larger. So, is synthesized in much more of various hormones and inflammatory cells. Among them, including interleukin-6, interleukin-1, tumor necrosis factor, and others, – says Tatiana Demidova. Often in the body, there is a creeping inflammation.
At the same time observed that many viral infections and especially COVID-19 amplify the effects cytokines and lead to the extension of the generalization of inflammation. “It was proved that adipose tissue serves as a reservoir for some viruses, such as influenza, HIV and cytomegalovirus. Also, according to the latest data, it can be activated and coronavirus,” adds Demidov.
INSULATION NEEDS TO BE LONGER?
Studies have shown one more feature of coronavirus. As it turned out, he is able to spread rapidly in adipose tissue surrounding internal organs – lungs, liver, kidneys, heart, etc. because Of this, developing severe damage to these vital organs and people with excess weight, excess amount of adipose tissue increases the risk of death from multiple organ failure.
There is evidence that such patients are also unable to stay longer carriers of the virus, require longer hospital stay and isolation, said Tatyana Demidova.
AFTER INFECTION — DIABETES
There is evidence and that not less than one-third of patients hospitalized with COVID-19 in China, European countries and the United States, the infection resulted in damage of the pancreas. This was confirmed by elevated enzymes amylase and lipase, and glucose levels in the blood plasma.
– This is a very disturbing circumstance. Since we talking about high risk of developing diabetes type 2 diabetes in people with the original obesity after recovery from infection, says Dr. Demidov.
It is not excluded that after the break the pace of the epidemic COVID, we will see a worldwide surge in the incidence of diabetes, experts say.
So now, when the opportunity walks, sports, seasonal ripe fruits and vegetables rich in fiber, doctors suggest the obese individuals to exert their maximum effort for getting rid of really dangerous extra pounds.
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The main symptoms COVID-19 in children are fever, diarrhea and vomiting. This is stated in a study group of pediatricians, conducted at four hospitals in Western China. The results published in Plos Medicine.
According to the study, heat or fever occur in 76% of coronavirus-infected children. In 62% of infected children have also recorded a strong cough, and 12% — diarrhea and vomiting. Lung problems from minor occur in the later stages of the disease, follows from the analysis.
In the study, pediatricians examined 34 children aged one month to 12 years. The analysis was conducted from 27 January to 23 February this year. All patients in the current study, rooting COVID-19 easy (18%) or moderate (82%) form.
Pandemic coronavirus. The most current at 18 June
Earlier, in April, Rospotrebnadzor reported that children tolerate coronavirus infection more easily than adults. They longer remain active carriers of the virus, warned in the Department. The most vulnerable to COVID-19 juvenile children are six or seven years, said the Agency.
Grandson Of Alla Pugacheva Nikita Presnyakov for three years happily married. His wife Alena Krasnov is a rare beauty, what I am always convinced its followers of Instagram. Alena – model, often removed in photo shoots. Footage from the last shooting she decided to share on his page. The pictures were unexpectedly spicy: the 23-year-old wife Presnyakov posing in her panties, covering her Breasts a wide-brimmed hat.
– I am not given to display such pictures, but do not go for the sake of art, especially when on the scale of 6 kg during the quarantine – coyly said Alena.
Subscribers, however, no extra pounds in the pictures could not see: she looks slim, toned and very sexy. Beautiful photos of the couple appreciated and Nikita Presnyakov.
I nesoi directly to display such pictures, but do not go for the sake of art, especially when the scales -6 kg during the quarantine Thanks MoEI lubimoi @nastyaafed for such frames Which picture do you like best?
– Missed wife, of course – he wrote in the comments.
It is unknown whether saw Frank shooting the grandmother Nikita Alla, and what she said about spicy photo shoot Alena. “Alla is in shock,” just kidding followers. In the comments they throw a young wife Presnyakov compliments and I assure you that the photos look beautiful and brand does not matter.
– Life is a moment! While you are young and you have from God such beauty, let everyone look and envy! – said one of podeschi.
Alena posing Topless. Photo: Instagram.
During the quarantine, Nikita and Alena lived in the suburban house, owned by Pugacheva. However, no matter Presnyakov Jr. sat In may he released the video for new single “Shadow” (Nikita, recall, lead singer of the Multiverse). The Prime Minister was supported by his famous grandmother, boasting talents grandson in social networks.
Last year Nikita Presnyakov became the hero of the program Lera Kudryavtseva “The secret to a million” the musician told the presenter about his family life quite intimate things – for example, about the first sex with his future wife. Nikita was the first love of Alena, which ended legal marriage. Pair got married after four years of relationship.
Fans pelted the wife of the grandson Pugacheva compliments. Photo: Instagram.
Nikita started Dating Alena Krasnova, when she was only 17 years old, she was still in school. Presnyakov waited two years for the moment when his girlfriend is ready for an intimate relationship. For a young lover Nikita, who is older than Alena for six years, voluntarily refused to have sex – he believed that they all must happen at the moment when the girl herself is ready for it.
– In terms of sex I waited until she said ready. Two years we suffered, – told the grandson Pugacheva. – I have a very big will power and if I put some goal, I achieve it, – said Nikita. – We with Alena for the first time it happened-planned, carefully and romantic. Alena was very nervous!
We are already a month in the country in isolation And this is definitely something there
Alain initially doubted his feelings for Nikita. It seemed to her that they all happen too fast. Besides her troubled six-year age difference. Grandson of Alla Pugacheva and his future wife met, that is, neighborly: villas their families are located nearby, Alena from a wealthy family. Like Nikita, his beloved was a creative soul: I was fond of gymnastics, dancing in the Studio Alla Brass “Todes” and studied at a music school.
Nikita also explained why he was in no hurry to do Dolly parton’s great grandmother: according to the musician, they Alena in no hurry to have children, because while I want to stand up and live for yourself.
Julia Proskuryakova more than ten years of happy marriage with Igor Nikolaev. The actress 22 years younger than the composer. She became his third wife. A big age difference does not bother them. Pair daughter Veronica. There is only one “but”. The young wife of the musician was exhausted from comparisons to Natasha Koroleva.
Igor Nikolaev has been married to Natasha Koroleva nine years. Children they have not got. In 2010, the composer married Julia Proskuryakova.
For many years, Julia hears the accusations in his addressrelated to the fact that it is supposedly not as good as Queen. To read such statements to any woman very offensive. No wonder the young wife Nikolaev such comparisons cause irritation and anger.
“Well, you wife is such a person.. so much shame why? No talent as a creative person… so Be on your place… We miss Igor – composer, with you he never wrote one hit. But he’s our Maestro, give dochu – this is cool. But half the country is capable of. But to be a Muse, as Natasha Koroleva… Not given to you, don’t, Yulia, to do what can not”, – wrote one of the fans.
If someone wants to dance
Proskuryakova these words struck a chord. She once again appealed to the public to stop the persecution. According to her, have it no more strength to read such – she feels enormous pressure.
“Can you give me a break, please! Leave me alone, Ah! I’m not Natasha, it will not and do not want to be. It has its own page to write. There are many nostalgic video, you can watch them as you want! I live my life. Live the way I want. Don’t need anybodies advice and estimates, true,” snapped pushed to the limit Proskuryakova.
It is worth noting that Natasha Koroleva has repeatedly admitted that he is very much loved by Igor Nikolaev. According to the artist, the break with him has been tough on her. The couple lived together for ten years. Igor after parting with his beloved went to an apartment in Miamiand Natasha – the house in Krekshino. Two years later after a breakup with her first husband she married a second time. The chosen star became a stripper Sergei Glushko. In this marriage the singer gave birth to her only child, a son Arkhip.
Only 23% of Russians highly value distance education platforms. The vast majority are confident that distance education prevents students from preparing for the final tests
Photo: Vladimir Trefilov / RIA Novosti
The main fear of graduates and their parents in conditions of self-isolation was the quality of preparation for final exams. This follows from a survey conducted by the research company Wanta Group. Research materials are at the disposal of RBC.
The top 5 fears of graduates and their parents included:
quality of preparation for final exams (42%),
the risk of not entering the desired educational institution (28%),
postponement of final exams (22%),
difficulties finding a job after graduation (21%)
transfer of entrance tests to universities and colleges (18%).
81% of respondents believe that self-isolation prevents graduates from preparing for exams. The reason for this, first of all, was the quality of the remote platforms that students offer. Only 23% of parents and graduates stated that they highly appreciate the quality of the distance educational platform that is offered at the educational institution.
At the same time, young people rely more on the opportunity to prepare for exams in conditions of self-isolation and transfer of exam dates. 70% of respondents aged 18 to 24 believe that postponing final exams will give schoolchildren the opportunity to prepare better. Among respondents aged 45 and older, only 51% share this opinion.
The first 10 days after the onset of symptoms of the disease, the 38-year-old American was feeling quite well. He was not at risk; he had no chronic diseases.
– The man was examined, the disease was mild. The patient had a slight cough. Therefore, he was sent home for treatment, ”says the head of the Department of Vascular Surgery at Westchester Medical Center Sean Wengerter.
And then the incredible happened.
One morning, a man woke up with icy and numb legs. The body was constrained by terrible weakness; there was not even the strength to get out of bed.
The examination showed that the patient had aortic occlusion – a large blood clot formed in the main artery at the place where the artery diverged in two directions – to the right and left leg. Because of this clot, blood enriched with oxygen did not enter the iliac arteries.
“This is extremely dangerous.” From this can die from 20% to 50% of patients, – notes Vangerter. – But such things are not typical for 38-year-olds.
An emergency operation to remove a blood clot could save the patient’s life. But doctors working with patients with COVID-19 are everywhere faced with rather strange and frightening phenomena in infected patients. For example, the formation of blood clots (actually blood clots) of various sizes throughout the body, renal failure, inflammation of the heart muscle and malfunctions of the immune system.
“Coronavirus occurs in each patient in its own way,” notes Scott Brackenridge, associate professor of emergency surgery at the College of Medicine at the University of Florida. – In some cases, the patient has a problem with breathing, in others, the internal organs begin to fail. In children, the immune system as a whole begins to rebel.
Coronavirus is not just a respiratory diseasePhoto: Ivan MAKEEV
MYSTERIOUS STROKES
A new type of coronavirus is considered to be a respiratory virus, although it is already becoming obvious – the infection affects the entire human body. The most common symptoms are fever, pneumonia, and acute respiratory distress syndrome.
In this case, the virus attacks some organs directly. First of all, the mucous membrane of blood vessels, which entails unnatural coagulation of blood.
– COVID-19 provokes a local inflammatory reaction that leads to the formation of blood clots, – explains Wengerter. – This is due to the direct effect of the virus on the arteries.
A number of doctors recorded strokes in young patients with coronavirus, as well as the formation of blood clots in the lungs. Blood clots were found even in the smallest vessels.
“Since each organ feeds on blood vessels, and the virus attacks them first and foremost, we end up with damage to internal organs,” adds Dr. Scott Brackenridge.
Another serious symptom that is observed in some patients who become ill with the new coronavirus is the “co-fingers.” The infected toes swell, becoming red or purple. It is possible that the reason for this is blockage of blood vessels. But doctors say that usually this does not have serious consequences.
Kawasaki Syndrome
One of the most alarming reactions to COVID-19 is observed in children. It has already been named as a children’s multisystem inflammatory syndrome. In newYork Doctors have identified more than 100 cases.
This syndrome is characterized by a rather long fever, inflammatory process, malfunction of one or more internal organs, as well as the general condition, which is usually observed with shock. Pediatricians also compare these symptoms with the syndrome. Kawasaki.
Kawasaki syndrome is a rare disease that affects children aged 3 to 10 years. It is characterized by damage to the medium and small arteries, thrombosis, the formation of aneurysms and rupture of the vascular wall. Cases of infection are rare. However, recently, doctors have noted an increase in the number of patients with this syndrome.
Both childhood multisystem inflammatory syndrome and Kawasaki syndrome lead to an overly aggressive immune system response to coronavirus. This may be accompanied by inflammation of the blood vessels and heart muscle.
KILLER CELLS
However, scientists note that coronavirus is not able to cause a strong immune response, but, on the contrary, suppress the entire immune system. And this can allow the infection to freely attack the internal organs.
Partly this theory was confirmed by Chinese experts, led by Dr. Zhang Zhang. Scientists analyzed samples of immune cells taken from the lungs of 9 patients infected with coronavirus. The results of the study showed an abnormally high level of leukocytes – macrophages and neutrophils responsible for the destruction of harmful pathogen – in severe patients. At the same time, these patients had a rather low level of CD8 T cells, which are called killer cells. They are responsible for killing virus-infected cells.
But doctors are reassuring, noting that they have drugs that can thin the blood, and also help the work of white blood cells that resist infection.
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Educational and entertaining Internet resources will help to occupy a child during the period of universal self-isolation due to coronavirus. This is stated in the memo of the Ministry of Emergencies to parents.
The ministry advised parents to find out what their children are interested in and choose the appropriate online portal according to age.
For animal lovers, portals of different zoos of the world are recommended for visiting, which now allow you to watch animals online. Fans of theatrical performances are offered performances in the recording or live.
In the Ministry of Emergency Situations called allowing to break a mode of self-isolation of a situation
“Bring the child to art and visit with him the famous museums of our country and the world: the Hermitage, the Polytechnic Museum, the Tretyakov Gallery,” reads the memo of the Ministry of Emergencies.
