very cheap and long-known drugs help save the lungs with coronavirus

Cloving hospital on the basis of the Medical Scientific and Educational Center (ISSC) Moscow State University named after M.V.Lomonosov took the first patients on April 21 and completed his work on June 13. It turned out that it was possible to achieve the best treatment results for COVID-19 in Moscow. Over the entire period, 4 patients died, and among severe patients who got mechanical ventilation, the mortality rate was less than 14% (for comparison, the average for the city and the world was up to 70 – 80%). Eighteen doctors out of 220 employees of the hospital were infected with coronavirus, there were no deaths among the medical staff.

What approaches were used at the University Hospital of Moscow State University to achieve such results? We continue the conversation with the head. Department of Therapy, Faculty of Fundamental Medicine, Moscow State University, Head of the Department of Age-Associated Diseases, Medical Scientific and Educational Center, Doctor of Medical Sciences, Cardiologist Yana Orlova.

MEDICINE FOR COUGH FOR 80 RUBLES

– Most of those who are ill or are afraid to get sick are worried about fibrotic changes in their lungs. They say that you have developed special therapy that can reduce the risk of developing fibrosis. Is it possible?!

– Yes, we launched an appropriate clinical study. There are no final results yet, but we have developed clinical practice.

“What did you do to save the lungs?”

– We used a combination of bromhexine and spironolactone (both are long-known very cheap drugs. – Ed.). Bromhexine is an expectorant that has been prescribed to patients with pneumonia and cough for many years. At the same time, experimental data showed that this drug can block a specific enzyme and impede the penetration of coronavirus into cells. True, it was on this effect that we counted to a lesser extent in inpatients, since such an effect is important mainly in the early stages of the disease. But the expectorant effect of bromhexine really helps patients with COVID. I heard that our colleagues in Peter launched a study of bromhexine for prophylactic purposes. We will wait for the results.

Coronavirus infected 18 doctors from 220 employees of the hospital, there were no deaths among the medical staffPhoto: Ivan MAKEEV

FIBROSIS OBSTACLE

– The second drug – spironolactone – is traditionally widely used in cardiology for the treatment of heart failure, severe hypertension. It has a small diuretic, magnesium and potassium-preserving effect, continues Yana. Orlova. – It has several mechanisms through which it can be useful in coronavirus infection.

Firstly, a mechanism that prevents the development of fibrosis in general in the body. There are works that, in particular, show that spironolactone reduces fibrosis in the heart. At the same time, it is known that the tendency to fibrosis is not local, but systemic – where there is more inflammation, there will certainly be fibrosis. And we see, of course, fibrotic changes in the “covide” in our patients. Therefore, we prescribed spironolactone as a drug for the prevention of this process.

Secondly, this drug blocks sex hormone receptors, in particular testosterone. Some published studies suggest that “high-testosterone” men suffer from “covid” more often and develop more severe fibrotic changes. Therefore, blocking these receptors for several weeks during COVID treatment may be useful in reducing the severity of complications. We are not talking about a longer intake, since male patients are unlikely to agree with a decrease in testosterone levels in the long term.

And perhaps the most important point. In almost all of our patients, we observed hypokalemia (a decrease in potassium levels. – Ed.). With coronavirus infection, potassium is intensely excreted from the body, and scientific articles even suggest that hypokalemia serves as the trigger for a cytokine storm. So spironolactone has a real chance to reduce the risk of this dangerous complication. But the main thing, in my opinion, is that lowering the level of potassium in the body is extremely harmful to the heart and triggers life-threatening rhythm disturbances, increasing the risk of sudden death. We, like all others, replenished potassium with droppers, but it was more effective to retain it in the body with the help of spironolactone.


Men certainly get worse than women;  the elderly are heavier than the young;  overweight people are heavier than patients without excess weight Photo: Ivan MAKEEV

Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patientsPhoto: Ivan MAKEEV

WHEN PRESCRIBED PATIENTS

– Yana Arturovna, how many patients did you have on average?

– About 10 – 14 days. But someone and 50 days.

– Have you noticed signs by which it can be assumed that the disease in the person brought is likely to go the hard way?

– Such studies were carried out in the world, our clinical practice confirmed them. Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patients. Men with a classic male type of baldness, a lot of facial hair, we can say brutal men get sick harder.

– Under what conditions did you discharge patients?

– We acted as close as possible to the recommendations Ministry of Health: so that the temperature for three days was not higher than 37.5 degrees; so that C-reactive protein (an indicator of inflammation) is lower than 10 mg / l, and saturation, that is, the level of oxygen in the blood, is higher than 96%.

“HEAD OF EPIDEMIOLOGY DEPARTMENT OF ITSELF WORKED AT SANPROPUSNIK”

– How often do you get sick doctors and nurses?

– In the first month no one got sick at all. We have a very powerful epidemiological service. The head of the sanitary-epidemiological department, a senior researcher, correctly organized the whole process, and for the first two weeks she personally worked in the sanitary inspection room at the exit from the “red zone” and helped doctors and nurses who were exhausted after the shift safely remove protective clothing.

Then both people’s fatigue and viral load accumulated. By the middle of the second month, sick people began to appear. There were no seriously ill patients. We treated part of the staff in our observation, part of it was treated at home. In total, 18 people were infected from the medical staff (less than 10%).

– Doctors take something for prevention? Vitamins C, D, Zinc?

– I saw the recommendations of American nutritionists, they speak out positively about taking zinc, melatonin and vitamin C. There were somewhat conflicting data on vitamin D. But we did not give any such recommendations to our employees. We have all the prevention was associated with minimizing contacts and other measures of epidemiological safety.

Physicians are the heroes of our time.“If you think that you are special and that a pandemic will not affect you, you are deeply mistaken,” listen to what the doctors who are fighting with coronavirus say

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The results of treatment at the university clinic of Moscow State University were the best in the capital. “Komsomolskaya Pravda” learned the details of how doctors and scientists saved severe patients [Часть 1]

Virologist told whether it is possible to disinfect masks from coronavirus in sunlight

And also why the epidemic is gaining strength in southern countries and whether the sun affects the incidence – all this in an interview with George Vikulova (details)

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salute from the cable-stayed bridge, hovering above the water Assol and space suits

The brightest evening of the country’s graduates ended, which the guys were looking forward to this year. So, as always, the Scarlet Sails Festival 2020 became a beautiful chord of the All-Russian holiday. This year it was both traditional and completely unusual at the same time. We tell you what the Scarlet Sails 2020 surprised.

The main innovation of this year is the change of locationPhoto: Oleg GOLD

Well, firstly, the main innovation is the change of location. For several years in a row, a snow-white brig passes through the water area Not you along the Peter and Paul Fortress, the Hermitage and right under the Palace Bridge. This year, another, no less picturesque place was chosen, with very recognizable sights. Petersburg – stadium “Gazprom-Arena “, Lakhta-center and cable-stayed bridge ZSD.


Access to all locations was closed due to the difficult epidemic situation both in the city and throughout the country. Photo: Artem KILKIN

Access to all locations was closed due to the difficult epidemic situation both in the city and throughout the country.Photo: Artem KILKIN

The second innovation: live Petersburgers and visitors could not see all this beauty. And all because this year there are special requirements: because of the pandemic, access to the park is closed, it was also impossible to see from the water, since part of the Neva and the Gulf of Finland were blocked. GIMS boats and various services went around the water area and made sure that no one violated the ban. Law enforcement officers were also on duty on land: if they met people in a territory where there should not be anyone, they politely asked to leave the place and go home.


Everyone was politely asked to leave the coast Photo: Artyom KILKIN

Everyone was politely asked to leave the coast.Photo: Artem KILKIN

And at home, by the way, everyone would have considered it in the best possible way: there was a live broadcast of a concert and a pyrotechnic show on the Internet and on TV. By the way, on the screen you can see what on the shore would definitely not be accessible to the eye. And all because along the Neva and the Gulf of Finland there were several scenes at once and on each of them there was an action.

The main stage was next to the Gazprom Arena stadium, it was also very unusual – as if soaring in the air, and with it the stars acting on it. Leading the holiday were Ivan Urgant and Daria Александрова.


The hosts of the holiday were Ivan Urgant and Daria Alexandrova Photo: Oleg GOLD

Leading the holiday were Ivan Urgant and Daria AlexandrovaPhoto: Oleg GOLD

Timur Rodriguez, Vera performed their hits Brezhnev, RASA group, Dima Bilan and Surganova. And there were surprises in the form of a show of pirates and drummers, yes, it is worth noting separately what costumes the artists had – just space ones. Be sure to watch Bilan’s performance if you missed. And also a salute, well, the passage itself of a sailboat!


The cable-stayed bridge of the WHSD was both a platform for light and a launch site for fireworks. Photo: Oleg ZOLOTO

The cable-stayed bridge of the WHSD was both a platform for light and a launch site for fireworksPhoto: Oleg GOLD

By the way, the pyrotechnic show lasted almost half an hour, hundreds of volleys were launched into the sky, the first cable-stayed bridge of the WHSD was used. It was both a platform for light, and for launching a salute.


But the highlight, of course, was the passage of a snow-white brig with Scarlet Sails along the Gulf of Finland Photo: Oleg ZOLOTO

But the highlight, of course, was the passage of a snow-white brig with Scarlet Sails along the Gulf of FinlandPhoto: Oleg GOLD

And at the end of the extravaganza, the romantic Assol soared above the water to meet her dream. By the way, this year the holiday was dedicated to the author of the fairy tale about Scarlet Sails Alexander Green – marks 140 years since his birthday.

If you missed the broadcast live, there is an opportunity to watch the best moments of the show.

Graduation Scarlet Sails in St. Petersburg ended with a grandiose salute.Alena CHICHIGINA

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Volkswagen is negotiating the purchase of the service of car rental Europcar

Carmaker Volkswagen is negotiating the purchase of a company car rental Europcar Mobility Group, reports Reuters, citing sources. In 2006, Volkswagen sold Europcar for €3,32 billion ($3.7 billion) in the framework of the program to reduce costs. Sources said that the interest is preliminary in nature, the German concern plans to conduct a comprehensive review and evaluation of the asset.

Europcar is one of the largest companies in the car rental market in Europe was founded in Paris in 1949. Has its own offices, franchisees and partners in more than 145 countries around the world. The owner of the brand Europcar is an investment company Eurazeo.

Europcar because of the pandemic coronavirus loses. The market capitalization is €390 million Euros ($441 million) and net debt at the end of March amounted to more than €1 billion About the problems in rental vehicles was reported in the fall of 2019. As reported by Bloomberg, November 14, Eurazeo held a “strategic review” for the sale of all his shares or part thereof. Then the company’s market value was estimated at €660 million ($734 million).

Note that may of the other major service car rental Hertz has filed for bankruptcy because of the crisis caused by the pandemic coronavirus. As explained in the company, a reduction in bookings led to a sharp decline in revenue.

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Toyota RAV4 on LPG after 200 000 km of mileage: a car Enthusiast has shared his ownership experience

Regular oil change and a relaxed style of riding without fear allow you to put gas in the “Japanese”.

Photo: 2013 Toyota RAV4 source: Toyota

Japanese brand in the minds of Russian drivers has long been a standard of reliability, but how realistic is it to drive a gas Toyota RAV4 200 000 km little or no investment? Such a car is shown leading the “Technical channel club service” on YouTube, which talked to the owner.

The subject of discussion was the most common in Russia version of the model – front-wheel-drive Toyota RAV4 in 40-m body with 2.0-liter engine and a CVT. Crossover, purchased in 2013, only had one owner who installed the LPG for another 22 000 km. The choice was made in favor of Italian equipment.

For all time of operation has never had to change any suspension components except struts of the rear stabilizer. To date, “Rapchik” only needs to be replaced longitudinal ragachow two bushes and one lower control arm. The rest of the car has not had a problem with suspension.

Photo: engine compartment Toyota RAV4, source: “Technical club of the service channel” on YouTube

Thanks regular replacement motor oil is 7 500-8 000 km the engine is not presented with unpleasant surprises. According to the motorist, to top up the oil between servicing Toyota RAV4 he does not have.

The driver prefers a relaxed style of ridingso CVT also showed itself as a reliable unit. 98 000 km were made by partial replacement of the transmission oil, and after 200 000 km – full replacement with a new gasket and filter.

Benefits from gas owner to call difficult, but the savings on Toyota RAV4 the money he was able to purchase 19-inch wheels and tires to make noise insulation and shading, set a new multimedia system with 10-inch display.

“Japanese” is known weak head opticsbut the motorist has corrected this deficiency by replacing the factory halogen lenses on the Bi-LED.

Photo: 2013 Toyota RAV4 source: Toyota

Though reflex area is left untouched, the light was much better. In the future, the owner plans to do the polishing headlights and stick them on the protective film.

For example, the Toyota RAV4, the ownership experience shared by the motorist, you can see that when caring for Japanese cars can’t hurt installing LPG.

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In the MOE reported about the disinfectant 3.5 thousand medical institutions of Russia :: Society :: RBC

EMERCOM of Russia from the beginning of April disinfected more than 3.5 thousand medical institutions, 2.7 thousand educational institutions and 15.7 thousand objects of social service. It is reported TASS with reference to the press service of the Ministry.

In addition, MCHS handled 31.4 thousand buildings and structures of transport infrastructure, 6 thousand km of roads and more than 90 thousand units of equipment, said the Ministry.

Thorough disinfection is carried out on large transport objects. So, in Moscow and St. Petersburg several times treated railway stations.

Peskov said about the disinfection tunnels in the Kremlin

Previously, the Moscow Department of transport has published the order according to which taxi operators in Moscow should ensure disinfection of the vehicle after each assignment. Also operators were obliged daily to clean and disinfect the machine on specialized items and ensure drivers disposable masks, gloves, disinfectants and antiseptics for the hands.

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What happened during the night. Breaking news RBC :: Society :: RBC

Coronavirus has reduced the appetite of Russians for salary, the banks threatened to introduce a fee for card servicing, Egypt is going to resume flights, IKEA returns a bailout; main news — a review of RBC

The Russians called salary desired after the pandemic coronavirus

The prevailing wage of the Russians decreased by 20%. So, if in January they on average would earn 92 RUB “net” per month, after the abolition of all quarantine restrictions rely only on 74 thousand RUB this is evidenced by the research service “Work.ru”.

  • In Moscow, traditionally the most desired salaries are high, with 82 thousand RUB, then goes Saint-Petersburg — 72 thousand rubles Men on average said the amount of 86 thousand, and women — 61 thousand rubles.
  • A salary of more than 100 thousand rubles. would like to have every fifth Respondent (21%). The income from 30 thousand to 50 thousand rubles would be satisfied 27% of respondents, and perfect the salary from 50 thousand to 70 thousand rubles. called 29%.
  • The vast majority (90%) stated that they noticed the impact of the pandemic coronavirus to the labour market or expect it in the future.

Banks threatened with fees for service of plastic cards

The Association of Russian banks (ADB) has asked the government not to restrict the Commission for the collection of payments for cashless payments (acquiring) as anti-crisis measures, according to “Izvestia”.

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National Security and Defense Council of Ukraine proposed Zelensky to extend sanctions against VKontakte :: Politics :: RBC

On May 15, Ukraine should expire sanctions against Russian Internet services that were introduced by Petro Poroshenko in 2017. National Security and Defense Council proposes to extend them

Photo: Sergey Konkov / TASS

The National Security and Defense Council of Ukraine submitted to the office of the President of the country a draft decree on the extension of sanctions against Russian Internet services and social networks Mail.ru, VKontakte and Odnoklassniki. This is stated in the message of the NSDC on the page on Facebook.

“Based on the results of consideration by the majority of members of the National Security and Defense Council of Ukraine, a decision on the application, cancellation and amendment of restrictive measures (sanctions) was adopted,” the report said.

Sanctions against a number of Russian companies, social networks and individuals were introduced in Ukraine in May 2017. The corresponding decree was signed by Petro Poroshenko, who then held the post of head of state. In addition to Mail.ru services, Yandex services were also sanctioned. As a result, they were blocked in the country. The validity of sanctions and, accordingly, blocking should expire on May 15, 2020. At the time of blocking, the VKontakte site was the third most popular in the country, second only to the search engines Google and YouTube, Mail.ru and Yandex shared fourth and fifth places, Odnoklassniki were in tenth.

According to SimilarWeb, in January 2017, Ukraine accounted for 17.6% of the total VKontakte traffic. As of May 2020, the share of traffic from Ukraine to VKontakte fell to 6.48%. At the same time, in Ukraine, the Russian social network remained in fourth place in terms of traffic among all sites, losing only Facebook from social networks. “Classmates” took ninth place. On the 12th place was the Ukrainian version of Yandex, and on the 14th was the Russian version. Portal Mail.ru dropped to 17th line.

Representatives of Mail.Ru Group, Yandex, Odnoklassniki and VKontakte declined to comment on RBC.

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“AlloCovid”, artificial intelligence for public health

Inform about the Covid-19. The “AlloCovid” number – 0806 800 540 – allows people over the age of 15 to contact a virtual assistant to check whether their profile or state of health requires special attention. During the interview, an intelligent voice robot asks questions in accordance with the directives of the Ministry of Health and detects signs of the severity of the disease.

→ LIVE – Coronavirus: the latest information in France and worldwide

He summarizes the medical information and invites the person to stay at home, reach a doctor or call 15 depending on the answers obtained. “The goal is not to replace doctors, assures Professor Xavier Jouven, of the National Institute of Health and Medical Research (Inserm), pilot of the device. We collect and give information. “

Real-time monitoring of the epidemic. By collecting data for Public Health France, AlloCovid feeds the follow-up of the evolution of the Covid-19 epidemic in France, Overseas included. The device helps to detect potential foci of resurgence of the disease. The project was developed in partnership with data protection specialists and in accordance with the recommendations of the National Commission for Data Protection (Cnil).

→ READ. 26 million masks planned for the end of April

Xavier Jouven warns that AlloCovid differs from the much debated StopCovid application. The latter offers the possibility of finding contacts of people tested positive for Covid-19 via their smartphone.

An innovative device. AlloCovid was developed by a team of researchers from Inserm and the University of Paris. The free phone number is open seven days a week and 24 hours a day. It complements devices already implemented in the fight against the spread of SARS-Cov-2, such as maladiecoronavirus.fr, SOS doctors or Sentinel network.

The collection of information is the result of collaboration between Inserm and IT developers from a SNCF subsidiary. “We’ve been using artificial intelligence for several years, observes Professor Jouven, who praises the innovative nature of the approach. Here, we’re looking to turn it against the current Covid-19 epidemic. “

A test and adjustments. AlloCovid was made available to the Samu 78 and tested for one week during the month of April, before being extended to the entire national territory as of Monday, April 27. Today, the voice robot has 900 answers for each question. It even adapts to accents. On the other hand, it does not take into account the emotion in the voice on the phone.

“The telephone makes it possible to reach older and often more fragile people”, judge Xavier Jouven, who indicates that AlloCovid may undergo some adjustments between now and the lifting of the containment.

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Facebook launches option for video calls with up to 50 people without time limit – Telemundo Nueva Inglaterra

Facebook revealed that it is launching a tool called Messenger Rooms with which users will be able to make video calls with up to 50 people. This is the latest move by the social network ‘due to the popularity, in the midst of a coronavirus pandemic, of other applications such as its Zoom or Houseparty with similar group video contact capabilities.

The news was given this Friday by the founder of Facebook, Mark Zuckerberg through Facebook Live.

Live with Mark Zuckerberg

Tune in here on April 24th at 11am PT, as Mark Zuckerberg goes live to share some new product updates we’ve been working on, to help everyone feel more connected with each other even while we’re apart.

Posted by Facebook on Friday, April 24, 2020

According to our sister station CNBC, the tool will be free will allow Facebook and Messenger users to create group video calls of up to 50 people at a time, increasing the current limit of the Messenger app from 8 people.

According to CNBC, the 50-person limit for Messenger Rooms will not be available immediately. Facebook users will see a lower limit at launch, but it will soon rise to 50 people, a company spokesperson told CNBC. The limit will vary for users at launch, the spokesperson said.

By comparison, Zoom allows up to 100 people to video chat for free for up to 40 minutes. Houseparty supports up to eight people.

Video calls in Messenger Rooms have no time limit and will include features like augmented reality filters that allow people to add masks to their faces. Video call hosts will also be able to block calls and delete users. Facebook and Messenger users can create Messenger rooms, and they can invite anyone to join, including people who don’t have a Facebook account.

Messenger Rooms will begin rolling out to users on Friday, and will expand to more regions in the coming weeks. “You can start and share video calls on Facebook through your wall, Groups and Events, so it is easy for people to visit it. We will soon add ways to create video call rooms from Instagram Direct, WhatsApp and Portal too”, explained the social network.

WhatsApp also expands capacity

Facebook also announced that it is doubling the limit of people in WhatsApp video calls from four to eight people.


In addition, the company is introducing a video calling feature on Facebook Dating so that users of that service can have virtual dating.

Zoom improves your security

The video conferencing platform Zoom, which has achieved a sudden popularity success with the COVID-19 pandemic, announced this week an update to its software, where, it says, it has improved the encryption system to respond to criticism received for lack of security.

The San Jose, California-based firm explained in a statement that Zoom version 5.0 adds support for encryption with 256-bit AES encryption GCM, providing “increased protection for meeting data and resistance against tampering. ”

The update available this week will also allow the account administrator to choose which regions of the data center their meetings and webinars use for real-time traffic at the account, group, or user level.

On the other hand, the company has grouped all the options related to security in the same icon, which is accessed through the menu bar of the digital meeting, the “waiting room” option has been activated by default and allows videoconference hosts report a user whose participation has not been allowed.

“I am proud to achieve this step in our 90 day plan, but this is only the beginning. We will earn the trust of our customers and bring them happiness with our firm goal of providing the safest platform, ”said Zoom CEO Eric S. Yuan.

Zoom’s success and sudden growth as a result of the increase in teleworking and digital encounters following the confinement orders for the COVID-19 pandemic has been accompanied by many complaints about failures in communication security and little respect for the privacy of users.

One of the most common problems that its users are encountering is that Internet users who have not been invited appear by surprise in teleconferences, a phenomenon baptized as “zoombombing” and which has caused educational institutions, governments and companies to stop using the platform. and, in the case of Google, their employees have even been banned.

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20 minutes – Two women fall 190 meters to their deaths

According to initial findings, the two 75-year-old women embarked on a hike in the direction of Braunwald from Rüti GL station. For reasons still unexplained, they fell

about 190 meters deep. They suffered fatal injuries, as reported by the cantonal police in Glarus on Friday.

The two retirees were reported missing on Monday, April 20. As part of the search, the missing persons were found on a helicopter search flight in a rune at around 740 m above sea level. found.

The circumstances of the accident are being investigated by the public prosecutor’s office in the canton of Glarus in cooperation with the cantonal police in Glarus.

(dmo)

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