Researchers at St. Jude Children’s Research Hospital have identified epinephrine-producing C1 neurons in the rostral ventrolateral medulla (RVLM) as modulators of fear and anxiety. According to a study published in the journal Neuron, these neurons create a circuit that, when activated, triggers long-lasting anxiety, providing a potential new target for therapies that avoid the side … Read more
National Football League players face a neurodegenerative mortality rate four times higher than the general population, according to a cohort study of nearly 20,000 players published in eClinicalMedicine. Research conducted by Mass General Brigham, Boston University, and the Concussion & CTE Foundation confirms that while NFL players often show lower all-cause mortality, they suffer from … Read more
New research published in Science Translational Medicine indicates that congenital cerebral ventriculomegaly (CCV)—a condition marked by fluid-filled brain ventricle swelling—is frequently linked to rare, damaging gene mutations. According to investigators at the Mass General Brigham Neuroscience Institute, these genetic findings suggest that CCV is often a marker of underlying neurodevelopmental disorders, including autism spectrum disorder, … Read more
Researchers have identified a potential therapeutic pathway for Alzheimer’s disease by targeting DNA damage within brain neurons. A study published in FEBS Open Bio reports that the molecule KCL-286 successfully repairs neuronal DNA in mouse models, simultaneously reducing brain inflammation and abnormal immune activity associated with neurodegeneration. How does KCL-286 target Alzheimer’s disease? The drug … Read more
Vestibular migraine is a sensory processing disorder characterized by vertigo, dizziness, and disequilibrium, often occurring without the typical head pain associated with traditional migraines. Affecting an estimated 3 percent of the American population, the condition frequently goes undiagnosed because it falls into a diagnostic gap between neurology and otology, according to Dr. Jeffrey Sharon of … Read more
Infants begin to shape their movements in response to music within their first year of life, though the ability to coordinate these actions with a rhythmic beat develops later, according to research published in the journal eLife. A study led by Trinh Nguyen of the Istituto Italiano di Tecnologia (IIT) and the University of Vienna … Read more
Researchers at the University at Buffalo have developed an artificial intelligence method to detect cortical lesions in multiple sclerosis (MS) patients using existing MRI scans. By analyzing relationships between multiple contrast images, this AI-driven approach reveals invisible gray matter damage, providing a new metric for tracking disease progression and cognitive impairment, according to a study … Read more
Intensive lifestyle interventions, such as those tested in the FINGER and POINTER clinical trials, produce only modest improvements in cognitive performance and have not yet been shown to reduce the incidence of dementia. According to the 2024 Lancet Commission report, 45% of global dementia cases could — in theory — be prevented based on 14 … Read more
The Bacillus Calmette-Guérin (BCG) vaccine, typically used to prevent tuberculosis, may remodel the brain’s immune environment to potentially lower Alzheimer’s disease risk, according to research published in Communications Medicine. A year-long study led by Mass General Brigham investigators found the vaccine increased immune cell responsiveness and altered Alzheimer’s-related biomarkers in older adults without pre-existing pathology. … Read more
Researchers have developed a triphasic biomaterial scaffold that successfully restores the cranial suture stem cell niche in cases of craniosynostosis. According to a study published in Bone Research on May 28, 2026, the scaffold—engineered from poly(L-lactic acid)—prevents premature skull bone fusion by maintaining essential skeletal stem cells, offering a potential alternative to invasive surgical procedures … Read more