A plant-forward, low-protein diet supplemented with precise amounts of the amino acid methionine increases healthspan and reduces frailty in mice, according to a study published in Cell Metabolism by researchers at the University of Southern California (USC). Led by Valter Longo of the USC Leonard Davis School of Gerontology, the team found that balancing specific … Read more
Long-standing psychological traits, including neuroticism and a lack of purpose, track distinct molecular pathways in Alzheimer’s dementia, according to a multi-omics study published in Translational Psychiatry. Researchers from the Religious Orders Study (ROS) and the Rush Memory and Aging Project (MAP) found that while traditional pathology and genetic risk factors identify overall disease susceptibility, these … Read more
Researchers have identified a decline in the PRDM16 protein as a primary driver of cardiac aging, according to a study published in Science Advances. By analyzing 442,239 single nuclei from human heart tissue, the team mapped how cellular balance shifts from fetal development through age 75. Restoring PRDM16 levels in aged mouse models improved heart … Read more
Immune aging, or immunosenescence, triggers a decline in the body’s ability to fight infections and tumors while simultaneously increasing the risk of chronic inflammation and autoimmune diseases. According to a review published in the Journal of Clinical Investigation, the human immune system reaches a critical inflection point around age 50, where molecular signatures of aging … Read more
Researchers have identified the vgll3 gene as a primary driver of an evolutionary trade-off where accelerated growth and early reproduction in the African turquoise killifish directly increase the risk of cancer and aging-related decline later in life. Published in Nature Communications, the study provides experimental evidence for “antagonistic pleiotropy,” a theory suggesting that genes providing … Read more
Less than half of Michigan adults aged 50 and older know that daily lifestyle choices can reduce dementia risk, according to the Michigan Poll on Healthy Aging. While most residents value brain health, a significant gap exists between their intentions and their actual daily habits regarding sleep, diet, and physical activity. Why is there a … Read more
Early-life adversity leaves a permanent, system-wide biological signature that alters how the body ages, according to a study published in the journal Science. Researchers tracking rhesus macaques found that childhood hardships—such as maternal loss or social instability—reshaped the epigenome across multiple tissues in a coordinated, yet non-uniform, manner that challenges the theory that adversity simply … Read more
A multi-institutional research team led by the Indiana University School of Medicine has secured a $9 million grant to investigate how immune cell aging contributes to the onset and progression of Parkinson’s disease. The project, supported by Aligning Science Across Parkinson’s (ASAP) and The Michael J. Fox Foundation for Parkinson’s Research, will examine immune-cell exhaustion … Read more
At 93, actress Joan Collins maintains a vibrant public life and career, attributing her longevity to a combination of genetics, regular Pilates-style exercise, and a disciplined approach to wellness. According to interviews with The Independent and The Telegraph, the “Dynasty” star emphasizes that her routine includes consistent sleep, hydration, and a positive outlook rather than … Read more
The National Institutes of Health (NIH) Cellular Senescence Network (SenNet) has launched a comprehensive, open-source atlas mapping “zombie cells”—damaged cells that stop dividing but persist in the body—to better understand their role in aging and chronic disease. Led by Rong Fan of Yale University, the project provides a foundational spatial map of these cells, which … Read more