Women who have used hormonal birth control or menopausal hormone therapy (MHT) show structural brain differences associated with healthier aging, according to research published in the journal NeuroImage. A study of 459 women aged 65 to 80 found that lifetime exposure to these hormones correlates with greater gray matter volume and cortical thickness in brain … Read more
Scientists are increasingly viewing gut microbes as active participants in hormone-driven cancers, moving beyond the traditional “estrobolome” model to define a bidirectional endocrine-microbiome axis. According to a review published in the journal npj Biofilms and Microbiomes, researchers are investigating how these microbial communities influence the metabolism of estrogen and contribute to the development of breast … Read more
A review of 85 clinical trials published in The Lancet found that most IVF “add-ons” offer little to no proven benefit for fertility outcomes. Researchers at the University of Melbourne, led by Sarah Lensen, identified that seven out of ten common add-ons lack sufficient evidence, often leading to unnecessary financial and medical burdens for patients … Read more
New experimental research identifies how statins—widely used cholesterol-lowering medications—can trigger muscle atrophy and weakness by disrupting cellular metabolism and activating the NLRP3 inflammasome. According to findings published in recent experimental models, statins block the mevalonate pathway, leading to a shortage of isoprenoids and a subsequent loss of protein prenylation. This metabolic stress state activates inflammatory … Read more
Researchers at The University of Texas MD Anderson Cancer Center have mapped the spatial architecture of muscle-invasive bladder cancer, identifying how tumor cell states and immune environments interact within specific regions of a tumor. Published in Cancer Discovery, the study reveals that bladder cancer is not a uniform disease, but a complex landscape where luminal … Read more
Researchers at the MUSC Hollings Cancer Center have identified a mechanism that allows prostate cancer cells to survive treatment by hijacking a protein called PIM1. According to a study published in Cancer Letters, traditional therapies that block PIM1 signaling inadvertently trigger a survival response, prompting the team to develop a “degrader” compound known as PIMTAC … Read more
Researchers at UC San Francisco have developed a personalized adaptive deep brain stimulation (aDBS) system that automatically adjusts in real time to stabilize gait in patients with Parkinson’s disease. Published in Nature Medicine, the study shows that an implanted neurostimulator can detect neural signals linked to individual steps and modulate therapy within fractions of a … Read more
Researchers at the Ecole Polytechnique Federale de Lausanne (EPFL) have developed an artificial intelligence-driven deep brain stimulation (DBS) system that automatically adjusts to a patient’s movement in real time. According to a study published in Nature Medicine, this technology improves mobility for Parkinson’s disease patients by decoding neural biomarkers to modulate electrical pulses during activities … Read more
New Clinical Guidelines Aim to Reduce Unnecessary Testing for Precocious Puberty The Endocrine Society has released updated clinical practice guidelines for managing central precocious puberty, emphasizing that not all children showing early signs of development require medical intervention. According to the guidelines, published in The Journal of Clinical Endocrinology & Metabolism, clinicians should prioritize observation … Read more
Houston Methodist has appointed physician-scientist Malcolm Brenner to lead its newly established Center for Cell and Gene Therapy, aiming to accelerate the transition of laboratory discoveries into clinical treatments. According to Houston Methodist, the center will integrate academic research with clinical care to develop therapies for both congenital and acquired diseases by uniting multidisciplinary expertise … Read more