Why Some Memories Seem to Vanish and Return Fluctuations in histamine neuron activity within the brain act as a “gatekeeper” for memory access, according to a study published in the journal Neuron. Researchers at Nagoya City University found that when these neurons show high activity, mice are 40% more likely to recall a learned reward … Read more
Researchers at the University of California San Diego have identified a liver-based enzyme as a primary driver of cocaine addiction, shifting the focus of potential treatments away from the brain. Published in Nature Communications, the study utilized nearly 900 genetically diverse rats to isolate the Ces1 gene group, which regulates how the body metabolizes cocaine … Read more
Researchers have identified a novel genetic disorder caused by biallelic loss-of-function variants in the TMEM63B gene, according to a report published in the American Journal of Human Genetics. This condition manifests as severe childhood interstitial lung disease, distinct from previously identified neurological symptoms linked to different mutations in the same gene. The discovery, facilitated by … Read more
Low levels of vitamin C in the blood are linked to reduced gray matter volume and diminished connectivity in the brain’s default mode network, according to a study of 2,044 Japanese adults published in PLOS One. Researchers led by Haruka Nagaya of Hirosaki University found these associations remained significant even after accounting for age, physical … Read more
Low blood pressure, or hypotension, is linked to a significantly higher risk of developing Alzheimer’s disease, according to a study published in the Journal of the American Heart Association. Researchers analyzing data from nearly 800,000 adults found that individuals with low blood pressure were up to three times more likely to be diagnosed with Alzheimer’s … Read more
Researchers at Brigham and Women’s Hospital have successfully used transcranial magnetic stimulation (TMS) to selectively target specific brain circuits for depression and anxiety, according to a study published in Nature Molecular Psychiatry. By shifting stimulation sites from the standard dorsolateral prefrontal cortex to the dorsomedial prefrontal cortex, clinicians can influence distinct symptom clusters, including irritability … Read more
Menopause is a critical neurological transition that significantly alters brain function, according to research published in the journal Menopause. A study from the University of Vermont’s Robert Larner, M.D. College of Medicine indicates that resting-state brain activity shifts across premenopause, perimenopause, and postmenopause, primarily driven by hormonal fluctuations like estrogen. These findings suggest the menopause … Read more
The Albert Einstein College of Medicine has launched the Batia and Idan Ofer program for Validation of Interventions Targeting Aging and Longevity (BIO-VITAL), a specialized initiative designed to accelerate the development of pharmaceutical therapies that address the biological mechanisms of aging. By providing biotechnology firms access to proprietary research models and human longevity data, the … Read more
Researchers at the Medical University of South Carolina (MUSC) have identified a fundamental defect in the protein repair systems of patients with idiopathic dilated cardiomyopathy (IDCM). According to a 2026 study published in the Journal of Molecular and Cellular Cardiology, this breakdown in cellular maintenance leads to the accumulation of misfolded protein plaques, mirroring processes … Read more
Researchers at ETH Zurich have identified a new chemical compound, dubbed “Compound 10,” that shows potential in slowing the progression of Alzheimer’s disease by targeting the enzyme GRK2. According to findings published in Cell Reports Medicine, the substance prevents the formation of harmful enzyme aggregates in brain cells, offering a distinct mechanism compared to existing … Read more