Hepatocellular carcinoma (HCC) is currently the third leading cause of cancer death, with patient outcomes hindered by late diagnosis and scarce early biomarkers. According to a 2026 review in the journal Gene Expression, advancements in multi-omics and liquid biopsy are shifting the clinical landscape by enabling more precise prognostic tracking and personalized immunotherapy selection, though … Read more
Researchers at VCU Massey Comprehensive Cancer Center have developed an experimental molecule called an autophagy-targeting chimera (AUTAC) that dismantles the MCL1 survival protein to kill multiple myeloma cells. According to a study published in Cell Death & Disease, this targeted protein degrader works with existing proteasome inhibitors to reduce cancer cell viability by 50% within … Read more
Bioengineers at the University of California San Diego have created the first genome-scale reference map detailing how individual genes influence the behavior and identity of human induced pluripotent stem cells (iPSCs). Published in Nature Biotechnology, the study utilized CRISPR technology to systematically switch off 11,692 genes, providing a reference atlas for researchers to predict how … Read more
Researchers at The University of Texas MD Anderson Cancer Center have identified that resistance to tagraxofusp in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) is driven by severe mutations in the TET2 gene and reduced expression of the TXNRD1 enzyme. Published in the journal Leukemia, the study provides a potential framework for using these … Read more
Researchers have identified a new chemical compound, DE19725241, that shows potential in targeting the fat mass and obesity-associated protein (FTO) to treat pancreatic cancer. According to a study published in BIO Integration, the compound demonstrated selective antiproliferative activity in pancreatic cancer cell lines by binding to specific protein sites, offering a potential new scaffold for … Read more
Adaptor proteins serve as critical molecular scaffolds that dictate whether tumor-associated macrophages (TAMs) attack cancer cells or promote tumor growth, according to a review published May 22, 2026, in Oncoscience. Researchers led by Khandu Wadhonkar and Mirza S. Baig at the Indian Institute of Technology Indore found that these proteins integrate complex signaling pathways, offering … Read more
Researchers at the University of Massachusetts Amherst have developed an artificial intelligence model called MycoPermeNet to accelerate the discovery of tuberculosis drugs. By combining this AI with a high-throughput screening technique known as PAC-MAN, the team can predict which chemical compounds can penetrate the bacterium’s unique mycomembrane, potentially speeding up the search for effective treatments … Read more
Researchers have developed a triphasic biomaterial scaffold that successfully restores the cranial suture stem cell niche in cases of craniosynostosis. According to a study published in Bone Research on May 28, 2026, the scaffold—engineered from poly(L-lactic acid)—prevents premature skull bone fusion by maintaining essential skeletal stem cells, offering a potential alternative to invasive surgical procedures … Read more
Biologists at the University of Minnesota have successfully engineered a synthetic cell, dubbed “SpudCell,” capable of performing core biological life cycles including nutrient intake, growth, DNA replication, and division. According to a preprint posted July 2 on bioRxiv, the cell is constructed entirely from non-living chemical components and functions with a 90,000-base-pair genome, significantly smaller … Read more
Researchers from the Department of Breast Surgery at Fudan University Shanghai Cancer Center and the Department of Oncology at Shanghai Medical College, Fudan University have developed a new classification system for breast cancer based on the cancer-immunity cycle (CIC). Published in Cancer Biology & Medicine in 2026, this framework uses a “CIC score” to categorize … Read more