Inherited genetics directly shape how our DNA interacts with acquired mutations to drive tumor evolution, according to research published in Nature. Scientists at the University of Cambridge and the University of Edinburgh found that an individual’s genetic background dictates both cancer risk and the specific evolutionary paths tumors take, offering new direction for precision medicine … Read more
Non-endocytic transmembrane delivery strategies are emerging to bypass canonical cellular uptake routes, directly addressing the low endosomal escape efficiency that has long hindered the clinical translation of therapeutic biomacromolecules like mRNA and gene-editing tools. According to a review published in Biomedical Analysis, these advanced platforms offer a direct path to the cytosol, potentially reshaping the … Read more
Researchers at Carnegie Mellon University, the University of Pittsburgh, and the University of Washington have mapped how 3D genome architecture differs in brain cells affected by Alzheimer’s disease. According to a study published in Science, the research team linked genome folding to gene activity and brain tissue organization using single-cell technology, spatial mapping, and a … Read more
Researchers at the Keck School of Medicine of USC have identified a 3D hierarchy of DNA “enhancers” that function as master switches for prostate cancer development. According to a study published in Genome Biology, these interconnected networks control gene expression, revealing potential new targets for precision cancer therapies that could move beyond current gene-specific treatments. … Read more
University of Virginia researcher Nathan Swami has secured a $1.1 million, four-year grant from the National Institutes of Health to develop microfluidic devices capable of identifying and isolating rare circulating cells. By integrating artificial intelligence with on-chip physical analysis, the project aims to improve diagnostic accuracy for cancer and infectious diseases by capturing cell subpopulations … Read more
A study published in the journal Nutrients has linked high consumption of ultra-processed foods (UPFs) to early, measurable changes in insulin secretion and sensitivity among nondiabetic children. Researchers analyzed data from the San Antonio Family Assessment of Metabolic Risk Indicators in Youth (SAFARI) study, finding that higher UPF intake correlates with markers of insulin resistance … Read more
Patient-derived tumor organoids are emerging as high-fidelity preclinical models for precision oncology, offering a way to test cancer treatments on three-dimensional cell clusters that mirror a patient’s specific disease. Recent research led by investigators at Weill Cornell Medicine demonstrates that these “avatars” can reliably predict treatment sensitivity, potentially expanding the pool of patients eligible for … Read more
Researchers at the University of Illinois Chicago have identified a molecular switch, the ion channel protein KCNMB1, that regulates cancer cell stiffness. By activating this pathway, scientists can make metastatic cells more rigid, rendering them vulnerable to destruction by the immune system, according to a study published in the journal Developmental Cell. The Physics of … Read more
Researchers at the Hebrew University of Jerusalem have identified four distinct populations of specialized mesenchymal support cells that regulate the human intestine. Published in Cellular and Molecular Gastroenterology and Hepatology, the study reveals that these cells—previously thought to function as a single group—form a complex, localized network that coordinates tissue renewal, immune responses, and stem … Read more
A specific probiotic strain, Limosilactobacillus reuteri A21041, extended the lifespan of Caenorhabditis elegans worms by 19.3% in a recent study published in Frontiers in Nutrition. Researchers from the AIage Longevity Science Corporation Ltd. and the Guangxi Academy of Sciences found the strain, isolated from a centenarian in Beihai City, China, also reduced fat accumulation by … Read more