Cell

Autism Study Reveals Shared Brain Cell Changes in Early Development

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Researchers at the Institute of Science and Technology Austria (ISTA) have identified shared molecular pathways across diverse autism spectrum disorder (ASD) genetic models, according to a study published in Nature. By utilizing single-nucleus multi-omics sequencing, the team discovered that while genetic mutations differ, they often trigger identical developmental delays in brain cell maturation. This finding … Read more

Targeting Immune Cells to Enhance Colorectal Cancer Therapy

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Researchers at the Medical University of Vienna have discovered that the epidermal growth factor receptor (EGFR) influences immune cells within the tumor microenvironment of metastatic colorectal cancer, rather than acting solely on cancer cells. Published in Cell Death & Differentiation, the study suggests that silencing EGFR in myeloid cells—specifically macrophages—slows tumor growth and boosts the … Read more

How Prostate Cancer Cells Evade Treatment: New Study Findings

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Researchers at the MUSC Hollings Cancer Center have identified a mechanism that allows prostate cancer cells to survive treatment by hijacking a protein called PIM1. According to a study published in Cancer Letters, traditional therapies that block PIM1 signaling inadvertently trigger a survival response, prompting the team to develop a “degrader” compound known as PIMTAC … Read more

New Single-Protein Analysis Reveals Secrets of Scramblases

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Researchers at Weill Cornell Medicine and Ruhr University Bochum have developed a single-protein analysis platform that measures the activity of individual scramblases, proteins essential for cell membrane health. This method allows scientists to observe real-time lipid movement at a granular level, moving beyond traditional “ensemble” techniques that only capture average data from groups of proteins. … Read more

Unique Proliferation Gene Alterations in Diverse Cancer Patients

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A patient’s genetic ancestry can significantly influence cancer progression and survival rates, according to research presented at the European Society of Human Genetics conference. By integrating ancestry data with tumor sequencing, doctors can more accurately predict patient outcomes, particularly in pancreatic and breast cancers, without requiring additional clinical tests. How does genetic ancestry influence cancer … Read more

New Lead Named for Houston Methodist Cell and Gene Therapy Research

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Houston Methodist has appointed physician-scientist Malcolm Brenner to lead its newly established Center for Cell and Gene Therapy, aiming to accelerate the transition of laboratory discoveries into clinical treatments. According to Houston Methodist, the center will integrate academic research with clinical care to develop therapies for both congenital and acquired diseases by uniting multidisciplinary expertise … Read more

New Cellular Discovery Could Revolutionize Cancer Treatment

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Montana State University researchers have identified a biological pathway that allows cells to produce the essential amino acid cysteine when primary systems fail, a process previously deemed impossible by the scientific community. Published May 21 in Nature Chemical Biology, the discovery reveals how mammalian cells utilize a backup mechanism to cleave carbon-sulfur bonds in cystine, … Read more

New Esophageal Gel Coating Delivers Targeted Anti-Inflammatory Therapy

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MIT engineers have developed a novel, gel-based drug delivery system designed to coat the esophageal lining and transport medication directly into the tissue. By utilizing a hydrogel combined with permeability-enhancing bile salts, this approach aims to treat disorders like eosinophilic esophagitis and Crohn’s disease while avoiding the systemic side effects of traditional immunosuppressant drugs, according … Read more

Caffeine-Controlled Molecular Switches for Engineered Cells

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Researchers at the Texas A&M Health Institute of Biosciences and Technology have developed a molecular switch called CODS (caffeine-operated dissociation system) that uses caffeine to control engineered cells. Published in the Journal of the American Chemical Society in 2026, the system allows scientists to trigger or pause gene-editing activity and immune cell responses on demand. … Read more

New Compound 10 Shows Promise in Slowing Alzheimer’s Progression

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Researchers at ETH Zurich have identified a new chemical compound, dubbed “Compound 10,” that shows potential in slowing the progression of Alzheimer’s disease by targeting the enzyme GRK2. According to findings published in Cell Reports Medicine, the substance prevents the formation of harmful enzyme aggregates in brain cells, offering a distinct mechanism compared to existing … Read more

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